Results 101 to 110 of about 280,718 (307)

Prescription of Generic Drugs

National Journal of Physiology, Pharmacy and Pharmacology, 2013
Healthcare cost is one of the major obstacles for healthcare providers. One of the major components of this increased cost of healthcare related expenses is cost of Medicines. Medicines consume major chunk of total money spent on healthcare.
Mayur Chaudhari, Jaykaran Charan
doaj   +1 more source

Price regulation and generic competition in the pharmaceutical market [PDF]

In March 2003 the Norwegian government implemented yardstick based price regulation schemes on a selection of drugs experiencing generic competition. The retail price cap, termed “index price”, on a drug (chemical substance) was set equal to the average ...
Dalen, Dag Morten, Habeth, Tonje, Strøm, Steinar   +2 more
core  

The FDA, Preemption, and Public Safety: Antiregulatory Effects and Maddening Inconsistency [PDF]

, 2011
Most people think of preemption as a technical constitutional doctrine, but it is pivotally important to health and safety, while also opening the door to broad judicial discretion.
Gostin, Lawrence O.
core   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source

Neurotoxicological Evaluation of Intrathecal Citrate Excipients: Calcium Homeostasis Disruption and Safety Implications in CNS Drug Delivery

Pharmaceutics
Background/Objectives: Intrathecal drug delivery is essential for treating CNS disorders, but the safety of commonly used excipients such as citric acid/sodium citrate (SC) remains unclear.
Jue Wang, Yuan Zhang, Qing He, Ying Du, Xia Zhang, Xinru Tan, Xinting Zhou, Susu Tang, Baoming Ning, Rui Yang, Xia Zhao, Dejiang Tan, Huimin Sun, Jiasheng Tu   +13 more
doaj   +1 more source

INB3P: A Multi‐Modal and Interpretable Co‐Attention Framework Integrating Property‐Aware Explanations and Memory‐Bank Contrastive Fusion for Blood–Brain Barrier Penetrating Peptide Discovery

Advanced Science, EarlyView.
INB3P is a multimodal framework for blood–brain barrier‐penetrating peptide prediction under extreme data scarcity and class imbalance. By combining physicochemical‐guided augmentation, sequence–structure co‐attention, and imbalance‐aware optimization, it improves predictive performance and interpretability.
Jingwei Lv, Qianyang Wu, Jian Liu, Binlu Yang, Yuanhao Li, Junlin Xu, Yajie Meng, Leyi Wei, Zilong Zhang, Quan Zou, Xiulai Li, Feifei Cui   +11 more
wiley   +1 more source

Regulation, generic competition and pharmaceutical prices: Theory and evidence from a natural experiment [PDF]

We study the impact of regulatory regimes on generic competition and pharmaceutical pricing using a unique policy experiment in Norway, where reference pricing (RP) replaced price cap regulation in 2003 for a sub-sample of off-patent products. We exploit
Kurt R. Brekke, Odd Rune Straume, Tor Helge Holmås   +2 more
core  

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

Mastering particle size analysis: lessons, challenges, and future directions from the FDA–CRCG workshop

AAPS Open
Particle-size distribution (PSD) measurement is a cornerstone of pharmaceutical development and regulatory assessment, influencing formulation stability, dissolution, product quality, and performance.
Xiaoming Xu, William C. Smith, James E. Polli, Christine L. Plavchak, Bin Qin, Yan Wang, Nicholas Holtgrewe, Sam G. Raney, Andre O’Reilly Beringhs, Yihua Bruce Yu, Marc Taraban, Vishalakshi Krishnan, Anna Schwendeman, Dana C. Hammell, Jeffrey D. Clogston, Alan F. Rawle, Jernej Grmaš, Yousif Ayoub, Bernard Domnic, Rama Subba Reddy, Joseph Duncan, Matthew McGann, Jeff Bodycomb, Carl C. L. Schuurmans, Michiel Hermes, Jonathan G. Mehtala, Prashun Roy, Kevin Lance, Collin Britten, Kiwan Park, Daniel Beach, Matthew Elmer, Keith B. Rodenhausen, Zhen Xu, Haiou Qu, Kai-Wei Wu, Maxwell Korang-Yeboah, Yuan Zou, Ji Li, Alaa H. Abuznait, Colette Quinn, Anabelle Ethier, Kendice Ip, Dinesh Dhamecha, Qi Li, Dongkai Zhu, Rutu Valapil   +46 more
doaj   +1 more source