Results 61 to 70 of about 32,629 (301)

Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye. [PDF]

, 2015
Accumulation of protein- and lipid-containing deposits external to the retinal pigment epithelium (RPE) is common in the aging eye, and has long been viewed as the hallmark of age-related macular degeneration (AMD).
Bird, AC, Boldt, K, Bundy, JG, Fearn, S, Flinn, JM, Jones, EA, Kortvely, E, Lanzirotti, A, Lengyel, I, McPhail, DS, Pauleikhoff, L, Ratu, SG, Reffatto, V, Thompson, RB, Ueffing, M   +14 more
core   +1 more source

Pathogenesis of Drusen in the Primate

Retina, 1986
Two monkey eyes that showed clinical evidence of drusen were studied by light and electron microscopy. The drusen-like spots had several different morphological patterns: the appearance of typical drusen, budding retinal pigment epithelial (RPE) cells, and vacuolation of retinal pigment epithelial cells. Several stages of budding were seen.
Nino Sorgente, Tatsuro Ishibashi, Stephen J. Ryan, Randi Patterson   +3 more
openaire   +3 more sources

Developing an image-based grading scale for peripheral drusen to investigate associations of peripheral drusen type with age-related macular degeneration

Scientific Reports
Age-related macular degeneration (AMD) is a leading cause of blindness. It is associated with peripheral drusen which has not been categorized. We investigated peripheral drusen to validate an image grading system and to understand possible associations ...
Paripoorna Sharma, Fritz Gerald P. Kalaw, Andrew Lin, Evan H. Walker, Shyamanga Borooah   +4 more
doaj   +1 more source

Drusen Segmentation From Retinal Images via Supervised Feature Learning

IEEE Access, 2018
This paper presents a supervised feature learning method to learn discriminative and compact descriptors for drusen segmentation from retinal images.
Xiuxiu Ren, Yuanjie Zheng, Yanna Zhao, Chao Luo, Hong Wang, Jian Lian, Yunlong He   +6 more
doaj   +1 more source

Genetic Susceptibility, Diet Quality, and Two-Step Progression in Drusen Size

Investigative Ophthalmology and Visual Science, 2020
Purpose To investigate the relationship of growth in drusen size with genetic susceptibility and adherence to the alternate Mediterranean diet. Methods Participants in this analysis had complete ocular, genetic, and dietary data with mean follow-up time ...
B. Merle, B. Rosner, J. Seddon
semanticscholar   +1 more source

Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model

Nature Communications, 2021
Age-related macular degeneration is characterized by lipid-rich drusen deposits underneath the retinal pigment epithelium (RPE). Here the authors report an in vitro iPSC-RPE model for AMD that recapitulates drusen and RPE atrophy, and identify two drugs ...
Ruchi Sharma, Aman George, Malika Nimmagadda, Davide Ortolan, Barbosa-Sabanero Karla, Zoya Qureshy, Devika Bose, Roba Dejene, Genqing Liang, Qin Wan, Justin Chang, Balendu Shekhar Jha, Omar Memon, Kiyoharu Joshua Miyagishima, Aaron Rising, Madhu Lal, Eric Hanson, Rebecca King, Mercedes Maria Campos, Marc Ferrer, Juan Amaral, David McGaughey, Kapil Bharti   +22 more
doaj   +1 more source

Automatic Drusen Segmentation for Age-Related Macular Degeneration in Fundus Images Using Deep Learning

Electronics, 2020
Drusen are the main aspect of detecting age-related macular degeneration (AMD). Ophthalmologists can evaluate the condition of AMD based on drusen in fundus images. However, in the early stage of AMD, the drusen areas are usually small and vague.
Quang T. M. Pham, Sang-il Ahn, S. Song, Jitae Shin   +3 more
semanticscholar   +1 more source

Cell Calcification Models and Their Implications for Medicine and Biomaterial Research

Advanced Healthcare Materials, EarlyView.
Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter, Caterina Vanelli Coralli, Robert Dzhanaev, Aaron Morgan, Willi Jahnen‐Dechent, Sergio Bertazzo   +5 more
wiley   +1 more source

Long-term Evolution and Remodeling of Soft Drusen in Rhesus Macaques

Investigative Ophthalmology and Visual Science, 2020
Purpose To characterize the evolution and structure of soft drusen in aged rhesus macaques using in vivo multimodal retinal imaging and ex vivo histologic and ultrastructural analyses as a nonhuman primate model of early age-related macular degeneration (
Glenn Yiu, S. Chung, I. N. Mollhoff, Yinwen Wang, U. Nguyen, B. Shibata, David Cunefare, Sina Farsiu, J. Roberts, S. Thomasy   +9 more
semanticscholar   +1 more source

Dietary fatty acids and lipoproteins on progression of age-related macular degeneration [PDF]

, 2017
Age-related macular degeneration (AMD) is a medical condition of central loss vision and blindness. Numerous studies have revealed that changes on certain dietary fatty acids (FAs) could have useful for AMD management.
Abia González, María del Rocío, Bermúdez Pulgarín, Beatriz, García Muriana, Francisco José, López Martín, Sergio, Montserrat de la Paz, Sergio, Naranjo Gutiérrez, María del Carmen   +5 more
core   +3 more sources