Results 71 to 80 of about 31,224 (320)
Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells. [PDF]
, 2012 The goal of the present study was to determine whether treatment with cigarette smoke extract (CSE) induces cell loss, cellular senescence, and extracellular matrix (ECM) synthesis in primary human retinal pigment epithelial (RPE) cells. Primary cultured
Birke, Kerstin +3 more
core +3 more sources
Pathogenesis of Drusen in the Primate
Retina, 1986 Two monkey eyes that showed clinical evidence of drusen were studied by light and electron microscopy. The drusen-like spots had several different morphological patterns: the appearance of typical drusen, budding retinal pigment epithelial (RPE) cells, and vacuolation of retinal pigment epithelial cells. Several stages of budding were seen.
Nino Sorgente +3 more
openaire +3 more sources
Investigative Ophthalmology and Visual Science, 2020 Purpose To assess which visual function measures are most strongly associated with overall retinal drusen volume in age-related macular degeneration (AMD).
S. Pondorfer +6 more
semanticscholar +1 more source
Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model
Nature Communications, 2021 Age-related macular degeneration is characterized by lipid-rich drusen deposits underneath the retinal pigment epithelium (RPE). Here the authors report an in vitro iPSC-RPE model for AMD that recapitulates drusen and RPE atrophy, and identify two drugs ...
Ruchi Sharma +22 more
doaj +1 more source
Science Translational Medicine, 2018 Hydroxyapatite nodules in retinal drusen may indicate risk for progression to advanced age-related macular degeneration. Imaging AMD progression Age-related macular degeneration (AMD) is the leading cause of vision impairment in older individuals.
Anna C. S. Tan +14 more
semanticscholar +1 more source
Diagnosing Optic Disc Drusen in the Modern Imaging Era: A Practical Approach
Neuro-ophthalmology (Aeolus Press. 1980), 2020 Optic disc drusen (ODD) are a well-recognised cause of an elevated optic disc appearance. When visible with ophthalmoscopy and fundus photography, ODD are readily identified. Yet, in more subtle cases of ODD, ancillary testing may be needed to render the
F. Costello +3 more
semanticscholar +1 more source
Optic Disc Pallor in Parkinson's Disease: A UK Biobank Study
Movement Disorders, EarlyView.Abstract Background Recent studies have suggested that retinal changes measured with optical coherence tomography are detectable in early Parkinson's disease (PD), highlighting the potential of ophthalmic biomarkers for diagnosis and monitoring. Objective We set out to investigate the relationship between optic disc pallor measured in fundoscopy images
Samuel Gibbon +3 more
wiley +1 more source
Reflections on the Utility of the Retina as a Biomarker for Alzheimer's Disease: A Literature Review. [PDF]
, 2019 As a part of the central nervous system, the retina may reflect both physiologic processes and abnormalities related to diseases of the brain. Indeed, a concerted effort has been put forth to understand how Alzheimer's disease (AD) pathology may manifest
Honma, Patrick +2 more
core +1 more source
Current Advances in the Combination of Fatty Acids and Resveratrol to Fight Ocular Diseases
Molecular Nutrition &Food Research, EarlyView.Graphical abstract illustrating the effects of Resvega administration on choroidal neovascularization and resveratrol metabolism in the retina. The diagram illustrates that oral administration of Resvega leads to a decrease in choroidal neovascularization.
Dominique Delmas +3 more
wiley +1 more source
Oman Journal of Ophthalmology, 2023 Optic nerve head (ONH) drusen are acellular calcified concretions. Buried drusen manifests as pseudopapilledema. The compressive effects of ONH drusen can rarely precipitate central retinal vein occlusion (CRVO).
Muthu Krishnan Vallinayagam +3 more
doaj +1 more source