Results 91 to 100 of about 1,948,356 (316)
Clinical Ophthalmology, 2022 Jeffrey K Luttrull,1 Gerry Gray2 1Ventura County Retina Vitreous Medical Group, Ventura, CA, USA; 2Regulatory Pathways, Inc, Laguna Beach, CA, USACorrespondence: Jeffrey K Luttrull, Ventura County Retina Vitreous Medical Group, 3160 Telegraph Road, Suite
Luttrull JK, Gray G
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Food Security and Climate Change in Dry Areas: Abstracts
, 2022 The dry areas of the developing world occupy some 3 billion hectares and are home to one-third of the global population. About 16% of the population lives in chronic poverty, particularly in marginalized rainfed areas.
(ICARDA), International Center for Agricultural Research in the Dry Areas
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Nature, 2013 Drought has wreaked havoc throughout history, destroying crops and causing famine and conflict. And it could be getting worse.
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 2019 The dataset contanins a data comparison between improved maize, millet and guar variety vs. local varieties for green fodder yield (GFY) and dry matter yield (DMY).
Majid, Abdul
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Spatial modelling of wetness for the Antarctic Dry Valleys
, 2011 This paper describes a method used to model relative wetness for part of the Antarctic Dry Valleys using Geographic Information Systems (GIS) and remote sensing.
Green, T.G. Allan +3 more
core +1 more source
Study of Bio-Mimicry Surfaces for Optimization of Coupling Performance in Wheelchair Racing Gloves
Proceedings, 2018 In wheelchair racing, the optimal pair of gloves, as well as knowledge of conditioning of glove-rim contact surfaces can have a significant impact on race performance.
Clara Usma +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source