Results 71 to 80 of about 2,236,746 (301)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Sustainable High-Speed Finishing Turning of Haynes 282 Using Carbide Tools in Dry Conditions
Metals, 2019 Nickel-based superalloys exhibit an exceptional combination of corrosion resistance, enhanced mechanical properties at high temperatures, and thermal stability.
Antonio Díaz-Álvarez +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
British Journal of Ophthalmology, 2003 Is that really the question or do eye symptoms lie? For those of us who see patients on a regular basis, how many times a day do we hear the recurring complaint, “Doctor, my eyes feel so dry…they itch, they burn, they feel constantly irritated”? As doctors we must ask, with a sense of wonder, do all of these patients really have dry eyes?
openaire +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Seasonal variation in soil and plant water potentials in a Bolivian tropical moist and dry forest [PDF]
, 2010 We determined seasonal variation in soil matric potentials (¿soil) along a topographical gradient and with soil depth in a Bolivian tropical dry (1160 mm y-1 rain) and moist forest (1580 mm y-1).
Markesteijn, L. +3 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2015 The dataset contanins a data comparison between improved maize, millet and guar variety vs. local varieties for green fodder yield (GFY) and dry matter yield (DMY).
Majid, Abdul
core
Experimental Study on Drying Lignite by Heat Pump
Zhileng xuebao, 2013 An experimental scheme is proposed to recover the waste heat of power plant circulating water to dry lignite with heat pump, and the experiment system was developed.
Sheng Wei, Zheng Haikun, Zhang Baosen
doaj
Nihon Kikai Gakkai ronbunshu, 2014 This paper deals with the effect of minimal quantity lubrication (MQL) on tool life (flank wear), crater wear of various coated high-speed steel tools and finished surface roughness in hobbing. Experiments were conducted by simulation hobbing by fly tool
Hironori MATSUOKA +7 more
doaj +1 more source