Results 71 to 80 of about 1,294,477 (268)
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Clinical Ophthalmology, 2022 Jeffrey K Luttrull,1 Gerry Gray2 1Ventura County Retina Vitreous Medical Group, Ventura, CA, USA; 2Regulatory Pathways, Inc, Laguna Beach, CA, USACorrespondence: Jeffrey K Luttrull, Ventura County Retina Vitreous Medical Group, 3160 Telegraph Road, Suite
Luttrull JK, Gray G
doaj
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Drying of Filament in Dry Spinning
Chemical engineering, 1966 1963年に“物性定数1集”が発行されてもう3年目となる。そもそも化学工学の研究者や化学工業の技術者にとって, 物性定数とは不可分の関係にあり, 化学工学実験を整理して式を導く場合やまたは既存の式により設計計算をする場合に必要欠くべからざる要素である。しかるにこの物性定数の測定及び整理については, 一般の化学工学実験を行なうセンスでは到底精度が得られず, 精密分析や精密工業のような非常に緻密なセンスが必要で, 従来は化学工学屋にとって苦手な所であった。しかし化学工業の発展に伴い, 我々の取扱わねばならぬ物質も増加し, 又化学工業の技術の進歩により, その温度, 圧力, 混合状態等の範囲は拡大の一歩をたどっている。一方化学工学の進化に伴い, 新しい物性定数の要求がある ...
Sano, Yuzi, Nishikawa, Shinzo
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FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Study of Bio-Mimicry Surfaces for Optimization of Coupling Performance in Wheelchair Racing Gloves
Proceedings, 2018 In wheelchair racing, the optimal pair of gloves, as well as knowledge of conditioning of glove-rim contact surfaces can have a significant impact on race performance.
Clara Usma +3 more
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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
British Journal of Ophthalmology, 2003 Is that really the question or do eye symptoms lie? For those of us who see patients on a regular basis, how many times a day do we hear the recurring complaint, “Doctor, my eyes feel so dry…they itch, they burn, they feel constantly irritated”? As doctors we must ask, with a sense of wonder, do all of these patients really have dry eyes?
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