Results 71 to 80 of about 31,034 (262)

Establishment of a drug evaluation model against light-induced retinal degeneration using adult pigmented zebrafish

Journal of Pharmacological Sciences, 2016
Age-related macular degeneration (AMD) is a major cause of irreversible loss of central vision in the elderly. Zebrafish is an attractive animal model in some respects, lower cost, smaller housing facilities and easier genetic manipulation compared to ...
Yuichi Saito, Kazuhiro Tsuruma, Masamitsu Shimazawa, Yuhei Nishimura, Toshio Tanaka, Hideaki Hara   +5 more
doaj   +1 more source

CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function

Nature Communications, 2021
Age-related macular degeneration (AMD) has been connected to deficits in autophagy. Here, the authors demonstrate, in mice and dry-AMD patient samples, that calcium and integrin binding protein 2 (CIB2) regulates Rheb-mTORC1 signaling axis, and ...
Saumil Sethna, Patrick A. Scott, Arnaud P. J. Giese, Todd Duncan, Xiaoying Jian, Sheikh Riazuddin, Paul A. Randazzo, T. Michael Redmond, Steven L. Bernstein, Saima Riazuddin, Zubair M. Ahmed   +10 more
doaj   +1 more source

Reflections on the Utility of the Retina as a Biomarker for Alzheimer's Disease: A Literature Review. [PDF]

, 2019
As a part of the central nervous system, the retina may reflect both physiologic processes and abnormalities related to diseases of the brain. Indeed, a concerted effort has been put forth to understand how Alzheimer's disease (AD) pathology may manifest
Honma, Patrick, Ngolab, Jennifer, Rissman, Robert A   +2 more
core   +1 more source

Dry Age-Related Macular Degeneration: Mechanisms, Therapeutic Targets, and Imaging [PDF]

Investigative Opthalmology & Visual Science, 2013
Age-related macular degeneration is the leading cause of irreversible visual dysfunction in individuals over 65 in Western Society. Patients with AMD are classified as having early stage disease (early AMD), in which visual function is affected, or late AMD (generally characterized as either "wet" neovascular AMD, "dry" atrophic AMD or both), in which ...
Catherine, Bowes Rickman, Sina, Farsiu, Cynthia A, Toth, Mikael, Klingeborn   +3 more
openaire   +2 more sources

Chlorella vulgaris biorefineries: sustainable biofuels and high‐value carbon capture

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Global reliance on fossil fuels has created urgent economic and environmental challenges, yet large‐scale use of algal biomass remains limited by production costs. Industrial scaling is constrained by inefficient harvesting and the technical challenges of processing recalcitrant cell walls.
Sandyelle Ferreira Alcântara Araújo, Antonio Átila Menezes Ferreira, Lucia Andrea Sindeaux de Oliveira, Dayana Nascimento Dari, Devany Quintela Soares, Eliana Elisa Francelino Mavie, Francisco Leonardo Alves de Moraes Sousa, Jessica Lopes da Silva, João Vitor Gomes de Araújo Silva, Thiago Queiroz da Silva, Ana Karine Portela Vasconcelos, Kelma Maria dos Santos Pires Cavalcante, John Hebert da Silva Felix, José Cleiton Sousa dos Santos   +13 more
wiley   +1 more source

Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. [PDF]

, 2017
Age-related macular degeneration (AMD) ranks third among the leading causes of visual impairment with a blindness prevalence rate of 8.7%. Despite several treatment regimens, such as anti-angiogenic drugs, laser therapy, and vitamin supplementation ...
Chwa, Marilyn, Cohen, Pinchas, Kenney, M Cristina, Kuppermann, Baruch D, Lu, Stephanie, Nashine, Sonali, Nesburn, Anthony B   +6 more
core   +1 more source

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

Poria acid alleviates oxidative damage in mice with dry age-related macular degeneration by activating the Nrf2/HO-1 signaling pathway [PDF]

, 2023
Chengyao Qin, Xi Chen, Tianming Hu, Wenxiu Sun, Zehao Liu, Min Li, Wei Wei, Yan Shao   +7 more
openalex   +1 more source

Impact of tomato variety and homogenization pressure on in vitro lipid digestion and lycopene bioaccessibility in tomato emulsions

Food Biomacromolecules, EarlyView.
Tomato variety and processing impact lycopene bioaccessibility. Tomato emulsions with high pectin content decreased the in vitro lipid digestion and negatively affected lycopene bioaccessibility. High pressure homogenization may enhance the release of lycopene into emulsion oil droplets, but it may also reduce the transfer of lycopene into the micellar
Grethe Iren A. Borge, Karoline K. Rød, Ane Meisland, Maud Langton, Elin M. Wetterhus, Annika Krona, Bente Kirkhus   +6 more
wiley   +1 more source

Refinement and preliminary evaluation of two tablet-based tests of real-world visual function [PDF]

, 2019
PURPOSE: To describe, refine, evaluate, and provide normative control data for two freely available tablet-based tests of real-world visual function, using a cohort of young, normally-sighted adults.
Bi, W., Crabb, D. P., Demaria, G., Jones, P. R., Taylor, D. J., Tigchelaar, I., Wilson, I.   +6 more
core   +2 more sources