Results 71 to 80 of about 18,555 (176)

Short‐Chain Fatty Acids: Microbial Metabolites Driving Gut‐Eye Axis Signaling

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Short‐chain fatty acids generated by gut microbial fermentation link diet to ocular physiology via the gut–eye axis. Through systemic distribution, these metabolites regulate GPCR signaling, epigenetic pathways, inflammation, and angiogenesis, shaping retinal homeostasis and highlighting therapeutic potential in ocular vascular and inflammatory ...
Aleah J. Brokemond, Ronny Amamoo, Fapianey J. Alexandre, Sewedo B. Ajisegiri, Menaka C. Thounaojam, Pamela M. Martin, Ravirajsinh N. Jadeja   +6 more
wiley   +1 more source

Mesenchymal Stem Cell‐Derived Extracellular Vesicles Ameliorate NaIO3‐Induced Dry AMD by Delivering miR‐486‐3p to Inhibit Lipocalin‐2‐Mediated Ferroptosis

MedComm, Volume 7, Issue 10, October 2026.
Our study reveals a novel mechanism by which MSC‐derived EVs alleviate NaIO3‐induced dry AMD‐like pathology. MSC‐EVs deliver miR‐486‐3p into retinal cells to directly inhibit the ferroptosis‐promoting target gene Lcn2. Concurrently, downregulated Lcn2 restores intracellular Gpx4 expression, thereby suppressing ferroptosis and rescuing retinal ...
Zheng Li, Tujing Zhao, Lin Ye, Runze Li, Huaping Tian, Ruilin Liao, Lulin Huang   +6 more
wiley   +1 more source

Recent Updates on the Diagnosis and Management of Age-Related Macular Degeneration

Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the Western world, with a higher prevalence among Europeans and North Americans than that in Africans, Hispanics, and Asians. Advanced AMD is categorized as atrophic
Nithya Boopathiraj, MBBS, Isabella V. Wagner, BS, Syril K. Dorairaj, MD, Darby D. Miller, MD, Michael W. Stewart, MD   +4 more
doaj   +1 more source

Recent advances in the management and understanding of macular degeneration [version 1; referees: 2 approved]

F1000Research, 2017
Current management of age-related macular degeneration (AMD) is directed at intravitreal injection of vascular endothelial growth factor (VEGF) inhibitors for the treatment of wet AMD and supplementation with oral antioxidants for the treatment of dry ...
Sepehr Bahadorani, Michael Singer
doaj   +1 more source

Retbindin Dynamically Redistributes to Preserve Retinal Flavin‐Dependent Homeostasis in Response to Riboflavin Availability and Circadian Demand

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
The retina is a part of the central nervous system, has remarkably high energy demands that require efficient retinal metabolism. Dysregulation of retinal metabolism disrupts energy supply and redox balance, leading to the pathogenesis of diverse retinal diseases. Riboflavin and its cofactors, flavin mononucleotide (FMN) and flavin adenine dinucleotide
Xue Zhao, Mustafa S. Makia, Gennadiy P. Moiseyev, Muna I. Naash, Muayyad R. Al‐Ubaidi   +4 more
wiley   +1 more source

Photobiomodulation in dry age‐related macular degeneration [PDF]

Acta Ophthalmologica, 2017
Mahesh Uparkar, Shalini Kaul, Pritam Rajput, Rahul Baile   +3 more
openaire   +2 more sources

Choriocapillaris changes in dry age-related macular degeneration and geographic atrophy: a review

Eye and Vision, 2018
Age-related macular degeneration (AMD) is a leading cause of central vision loss worldwide. The progression of dry AMD from early to intermediate stages is primarily characterized by increasing drusen formation and adverse impact on outer retinal cells ...
Malvika Arya, Almyr S. Sabrosa, Jay S. Duker, Nadia K. Waheed   +3 more
doaj   +1 more source

Treatments for dry age-related macular degeneration and Stargardt disease: a systematic review

Health Technology Assessment, 2018
Background: Age-related macular degeneration (AMD) is the leading cause of visual loss in older people. Advanced AMD takes two forms, neovascular (wet) and atrophic (dry).
Norman Waugh, Emma Loveman, Jill Colquitt, Pamela Royle, Jian Lee Yeong, Geraldine Hoad, Noemi Lois   +6 more
doaj   +1 more source

Functional Visual Outcomes of Wearing Colored Filters in Patients with Dry Age-Related Macular Degeneration

Journal of Shalamar Medical & Dental College
Background: Age-related macular degeneration (AMD) leads to a permanent decrease in vision, thus affecting the quality of life. Any intervention or modality that enhances the quality of vision and, in turn, quality of life is vital.
Syeda Baneen Jannat, Muhammad Shaheer, Asima Rafique   +2 more
doaj   +1 more source

Bidirectional causal associations between immune cell phenotypes and age-related macular degeneration subtypes: A mendelian randomization study

Experimental Gerontology
Background: Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly population, characterized by two primary subtypes: dry AMD (dAMD) and wet AMD (wAMD).
Zihao Zhuang, Xinyu Jia, Haixia Lin, Pengcheng Hu, Jianmin Hu   +4 more
doaj   +1 more source