Results 41 to 50 of about 6,256,408 (246)
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
False Myths versus Medical Facts: Ten Common Misconceptions Related to Dry Eye Disease
Biomedicines, 2020 Since the first definition of dry eye, rapid progress has been made in this field over the past decades that has guided profound changes in the definition, classification, diagnosis and management of the disease.
Giuseppe Giannaccare, Vincenzo Scorcia
doaj +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Kerala Journal of OphthalmologyContext: Dry eye disease (DED) is clinically subdivided into two types viz. aqueous deficient type and evaporative type. There are studies, which have shown that there is an association between vitamin D deficiency and dry eye disease.
Sushama N Rahate +3 more
doaj +1 more source
Saudi Journal of OphthalmologyAbstract: Tear film instability and reduced tear production initiate a vicious circle where hyperosmolarity, ocular inflammation, and apoptosis may induce a damage of the ocular surface including keratitis which is all included in a common condition called dry eye disease (DED).
Leonardi, Andrea +3 more
openaire +2 more sources
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
The Relationship Between Dry Eye Disease and Digital Screen Use
Clinical Ophthalmology, 2021 Zaina Al-Mohtaseb,1 Scott Schachter,2 Bridgitte Shen Lee,3 Jaclyn Garlich,4 William Trattler5 1Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA; 2Presbyopia and Ocular Surface Disease, Allergan, an AbbVie ...
Al-Mohtaseb Z +4 more
doaj
Scientific Reports, 2021 The incidence of dry eye disease is increasing worldwide because of the aging population and increasing use of information technology. Dry eye disease manifests as tear-layer instability and inflammation caused by osmotic hypersensitization in tear ...
Miyuki Kubota +8 more
doaj +1 more source
Meibomian Gland Dropout in Patients with Dry Eye Disease in China
, 2014 Purpose: To examine the morphological changes in the meibomian glands of eyes of patients with dry eye disease using the non-contact infrared meibography system and to assess their relationship with meibomian dropout, signs, and tear-film function ...
Gao, Ziqing +4 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni +7 more
wiley +1 more source