Results 61 to 70 of about 2,808,564 (242)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Effects of different nitrogen levels and plant density on flower, essential oils and extract production and nitrogen use efficiency of Marigold (Calendula officinalis).

پژوهشهای زراعی ایران, 2009
Efficient use of nitrogen for medicinal plants production, might increase flower dry matter, essential oil and extract yield and reduce cost of yield production.
ali akbar ameri, mehdi nassiri mahalati, parviz rezvani moghadam   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Gains in dry matter yield and herbage quality from breeding perennial ryegrass [PDF]

, 2011
peer-reviewedDuring the last 100 years, in Western Europe and elsewhere, considerable effort has been devoted to improving perennial ryegrass (Lolium perenne L.) for agriculture.
Lovatt, J.A., Wilkins, P.W.
core   +1 more source

Bacterial dry matter content and biomass estimations [PDF]

Applied and Environmental Microbiology, 1984
Approximately 20% dry-matter content appears to be an accepted standard value for bacterial cells. We have found that the dry-matter content of bacteria may be more than twice as high as generally assumed. The main reason for the low estimates seems to be that proper corrections for intercellular water have not been made when estimating the wet weight ...
G, Bratbak, I, Dundas
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Comparative analyses of cucumber (Cucumis sativus L.) cultivars with varying node formation rate in greenhouse

BMC Plant Biology
Background Shoot architecture is one of the fundamental traits in plants that diversifies their visual appearance. It is also an important agronomic trait as it substantially affects productivity and labor costs in crop species. Cucumber (Cucumis sativus
Eigo Ando, Kazuya Maeda, Naoto Aimi, Dong-Hyuk Ahn   +3 more
doaj   +1 more source

Balance between salt stress and endogenous hormones influence dry matter accumulation in Jerusalem artichoke

, 2016
Salinity is one of the most serious environmental stresses limiting agricultural production. Production of Jerusalem artichoke on saline land is strategically important for using saline land resources.
Rengel, Z, Shao, HB, Shao, HB (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. Email:longxiaohua@njau.edu.cn, Long, XH, Liu, ZP, Wu, YW, Shao, TY, Li, LL, Long, XH (reprint author), Nanjing Agr Univ, Coll Resources & Environm Sci, Nanjing 210095, Jiangsu, Peoples R China., shaohongbochu@126.com, Chen, MX   +10 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Optimization of controlled-release fertilizer and urea ratio to increase maize yield by improving dry matter accumulation and translocation in black soil

Frontiers in Plant Science
Nitrogen is the principal mineral nutrient limiting maize yield formation and effective nitrogen management is thus key for maximizing yield. However, conventional urea releases nutrients rapidly and the supply of nutrients is often mismatched with crop ...
Chunyan Yin, Chunyan Yin, Liang Feng, Liang Feng, Xiaoyu Liu, Xiaoyu Liu, Yu Li, Xin Shen, Guohai Fu, Ju Zhao, Ju Zhao, Lele Tian, Qingmei Li, Qingmei Li   +13 more
doaj   +1 more source