Results 61 to 70 of about 1,058,340 (242)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Sliding Mode Control for Slosh-Free Motion using a Nonlinear Sliding Surface [PDF]

, 2013
A new nonlinear switching surface is proposed for the design of a sliding mode controller for a class of mismatched uncertain systems. A control system for slosh-free motion of a partially filled liquid container is sought.
GANDHI, PS, Gandhi, P.S., Spurgeon, Sarah K., BANDYOPADHYAY, B, Gandhi, P. S., Kurode, Shailaja, Bandyopadhyay, Bijnan, KURODE, S, SPURGEON, SK, Bandyopadhyay, Bijan   +9 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Prediction of Sliding Wear of Artificial Rough Surfaces [PDF]

, 2012
When two surfaces are brought in contact, deformation takes place at asperity level. The local pressure distribution and deformation of the contacting surfaces are importance with respect to wear.
Imam , Syafa’at, D.J., Schipper, J. , Jamari, Rifky , Ismail, Budi , Setiyana, Eko , Saputra   +5 more
core   +1 more source

ELECTROSTATIC CHARACTERISTICS OF COPPER WIRES REINFORCED EPOXY MATRIX COMPOSITES [PDF]

Journal of the Egyptian Society of Tribology, 2015
This study investigates the electrostatic characteristics of copper wires reinforced epoxy matrix composites through the measurement of the electrostatic charge generated from sliding of the copper wires reinforced epoxy matrix composites against rubber ...
I. A. Rehab, M. M. Mahmoud, A. T. Mohamed, W. Y. Ali   +3 more
doaj   +1 more source

Surface morphology in engineering applications: Influence of roughness on sliding and wear in dry fretting [PDF]

, 2011
Influence of initial surface roughness on friction and wear processes under fretting conditions was investigated experimentally. Rough surfaces (Ra=0.15-2.52 [mu]m) were prepared on two materials: carbon alloy (AISI 1034) and titanium alloy (Ti-6Al-4V ...
Mathia, T.G., Kubiak, KJ, Kubiak, Krzysztof, Liskiewicz, T.W., K.J. Kubiak, T.G. Mathia, Mathia, TG, T.W. Liskiewicz, Liskiewicz, TW   +8 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Wear Response of Carbide-Reinforced 1.75 mol% Y₂O₃-Stabilized ZrO₂ Composites Under Dry Sliding Conditions

Lubricants
This study investigates the mechanical and tribological behavior of three composites with a ZrO2 matrix stabilized with 1.75 mol% Y2O3 and containing 1 wt.% Al2O3, reinforced with TiC (A), TiC + ZrC (B), and TiC + WC + Mo2C (C).
Dávid Medveď, Jana Andrejovská, Viktor Puchý, Róbert Džunda, Ondrej Petruš   +4 more
doaj   +1 more source

Lubricated sliding wear behaviour of aluminium alloy composites

, 2005
Interest in aluminium alloy (Al-alloy) composites as wear resistant materials continues to grow. However, the use of the popular Al-alloy-SiC composite can be limited by the abrasive nature of the SiC, leading to increased counterface wear rates.
Rainforth, W.M., Jones, H., Walker, J.C.
core   +1 more source