Results 91 to 100 of about 190,240 (315)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Study on Drying Performance and Prediction Model of Heat Pump Clothes Dryer Based on Theory and Experiment

Zhileng xuebao
The drying process of heat pump clothes dryer (HPCD) has complex characteristics for strong coupling (the thermal cycle of the refrigerant side is coupled with the drying cycle of the air side), time-varying (the system operating parameters change with ...
曹正, 高科科, 薛维超
doaj  

Impact of Tissue Decay on Drying Kinetics, Moisture Diffusivity, and Microstructure of Bell Pepper and Strawberry

Foods
This study investigates the potential to transform plant-based waste into a sustainable resource for animal feed through dehydration. Currently, research on the drying performance of decayed plant tissues remains scarce.
Sindy Palma-Salgado, Luis Vargas, Taha M. Rababah, Hao Feng   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Energy efficiency and drying kinetics of recycled paper pulp

, 2015
In this work, the influences of the air temperature and velocity on the drying kinetics of recycled paper pulp were analyzed. The increase of both variables positively influences the process, concerning the final moisture content and the drying time ...
Rocha, SCS, Estrella, L, Vieira, MGA
core   +1 more source

Optimization of the process of drying of corn seeds with the use of microwaves

, 2020
The heating and drying of various types of food using microwave improve the economy of time and energy. The physiological quality variation of the seeds submitted to microwave drying is known to some extent.
dos Santos, Amanda Rithieli Pereira [UNESP], da Silva, Edvaldo Aparecido Amaral [UNESP], Raghavan, Vijaya, Sartori, Maria Márcia Pereira [UNESP], Gariepy, Yvan, de Faria, Rute Quelvia   +5 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Análise de um secador de ervas finas assistido por termossifões [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Mecânica, Florianópolis, 2014.Neste trabalho propõe-se estudar a secagem de ervas finas em dois tipos diferentes de secadores ...
Rodríguez Cisterna, Luis Hernán
core  

Drying of Xanthan Gum Using a Two-Dimensional Spouted Fluidized Bed (2DSFB) with Inert Particles: Performance and Rheological Considerations

, 2015
Xanthan commercial gum was dried using a two-dimensional spouted fluidized bed dryer (2DSFB) with inert particles under different conditions of temperature, suspension feed rate, and air flow in the spout and annulus.
Cunha, RL, Menegalli, FC, Ciro-Velasquez, HJ   +2 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source