Results 61 to 70 of about 353,538 (308)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Determination of the drying speed in thin layer of shrimp

Revue des Énergies Renouvelables, 2010
This survey consists in determining the drying speed in thin layer of non shelled shrimp with the help of a climatic chamber. The experiences made permitted to elaborate a universal model.
L.F.G. Andriazafimahazo, I.A.J. Razafiarison, B. Zeghmati, B.O.A. Ramamonjisoa, F. Rabary, A. Rakotomahevitra   +5 more
doaj  

Drying Characteristics and Process Optimization by Heat Pump Drying of Green Sichuan Pepper

Shipin gongye ke-ji, 2023
In order to investigate the drying characteristics of green Sichuan pepper by heat pump and optimize the drying process parameters to improve the quality of dried green Sichuan pepper, the single-factor experiments and orthogonal tests on the drying ...
Zixuan WANG, Yingjun PU, Mingjin YANG, Jun TAN, Ling YANG, Weidong SONG   +5 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A Comparison of Four Mower Conditioners on Drying Rate and Leaf Loss in Alfalfa and Agrass [PDF]

, 2000
Mechanical conditioning of forage can be accomplished by passing the crop through fluted intermeshing rolls or by passing the crop over the tines of an impeller rotor.
Bailey, Theodore, Greenlees, Wallace, Hanna, H. Mark, Hanna, H. Mark, Marley, Stephen, Shinners, Kevin   +5 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Drying of the disperse material in the aero spouted bed with horizontal material moving [PDF]

, 2013
Проведено аналіз діючих сушильних пристроїв, показані їх достоїнства й недоліки.. Розглянуто конструкцію сушильної установки з використанням киплячого прошарку з газоди-намічним транспортуванням матеріалу.Проведен анализ действующих сушильных устройств ...
Kolomiyets, R.V.
core  

Diffusiophoresis in non-adsorbing polymer solutions: the Asakura-Oosawa model and stratification in drying films [PDF]

, 2017
A colloidal particle placed in an inhomogeneous solution of smaller non-adsorbing polymers will move towards regions of lower polymer concentration, in order to reduce the free energy of the interface between the surface of the particle and the solution.
Sear, Richard P., Warren, Patrick B.
core   +2 more sources