Results 51 to 60 of about 3,047,303 (249)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Intensification of the freeze drying process by the control of both freezing and primary drying steps [PDF]

, 2013
The problem of optimization of freeze-drying cycles is addressed, with emphasis in both freezing and primary drying steps. In particular, this study shows that the control of the nucleation event produces more uniform batches (as ice nucleation is ...
Barresi, Antonello, Pisano, Roberto, Bullich, R., Oddone, Irene   +3 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Drying of Curcuma (Curcuma xanthorrhiza roxb) Using Double Plate Collector Solar Dryer [PDF]

, 2012
Curcuma (Curcuma xanthorrhiza roxb) currently used as traditional medicine and as a dye. If the Curcuma will be saved then the water content should not be more than 10-11%.
Tjukup , Marnoto, Wasir , Nuri, Bayu , Ardinanto, M, Mahreni, Ratna E. , Puspitasari   +4 more
core   +1 more source

Drying strategies capable of reducing the stress level of a stack of boards as defined by a comprehensive dual scale model

Maderas: Ciencia y Tecnología, 2014
During drying, stresses and deformations develop in a wood board due to shrinkage fields which result from moisture content and temperature field variations.
Romain Rémond, Patrick Perré
doaj  

Optimization of heat shock, acid shock and salt stress process and its mechanism of protection before spray drying of Baijiu yeast - Modified sporidiobolus Johnsonii A

Bioresources and Bioprocessing
The low survival rate of high-quality baijiu yeast, Modified Sporidiobolus Johnsonii A (MSJA), during spray drying and the unclear mechanisms underlying its stress treatment processes (heat shock, acid shock, and salt stress) have significantly hindered ...
Fengkui Xiong, Zhongbin Liu, Jingyu Li, Guangzhong Hu, Duqing Qu, Bo Huang   +5 more
doaj   +1 more source

Macro-micro tests of cohesive soil under varied normal and shear stresses subjected to drying-wetting cycles

Journal of Rock Mechanics and Geotechnical Engineering
The mechanical behavior of cohesive soil is sensitized to drying-wetting cycles under confinements. However, the hydromechanical coupling effect has not been considered in current constitutive models.
Fangyue Luo, Ga Zhang, Yangping Yao
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source