Results 51 to 60 of about 138,161 (301)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Ecophysiological approaches to production and formulation of the biocontrol yeast Pichia anomala [PDF]

, 2004
To produce commercial biocontrol agents (BCAs) successfully, it is important that cheap and economic substrates are used which support high numbers of good quality inoculum.
Mokiou, Stella
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Yield, quality and plant nutrient contents of lettuce under different deficit irrigation conditions

Acta Scientiarum Polonorum: Hortorum Cultus, 2022
This research was carried out in two separate periods (spring and autumn) in 2018 to reveal the lettuce response of yield, some quality, and plant nutrient content under different water stress conditions.
Halil Demir, Harun Kaman, İlker Sönmez, Salahudin Saed Mohamoud, Ersin Polat, Zafer Üçok   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Investigation of oscillating climates for wood drying using the flying wood test and loaded beams: Need for a new mechano-sorptive model

Maderas: Ciencia y Tecnología, 2014
In this work, the effects of moisture content variations produced by oscillating drying conditions have been studied by means of non-symmetrical drying (flying wood) and loaded drying (3-point bending test).
Romain Rémond, Mariella De La Cruz, Daniel Aléon, Patrick Perré   +3 more
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Drying strategies capable of reducing the stress level of a stack of boards as defined by a comprehensive dual scale model

Maderas: Ciencia y Tecnología, 2014
During drying, stresses and deformations develop in a wood board due to shrinkage fields which result from moisture content and temperature field variations.
Romain Rémond, Patrick Perré
doaj  

Optimization of heat shock, acid shock and salt stress process and its mechanism of protection before spray drying of Baijiu yeast - Modified sporidiobolus Johnsonii A

Bioresources and Bioprocessing
The low survival rate of high-quality baijiu yeast, Modified Sporidiobolus Johnsonii A (MSJA), during spray drying and the unclear mechanisms underlying its stress treatment processes (heat shock, acid shock, and salt stress) have significantly hindered ...
Fengkui Xiong, Zhongbin Liu, Jingyu Li, Guangzhong Hu, Duqing Qu, Bo Huang   +5 more
doaj   +1 more source