Results 61 to 70 of about 138,161 (301)

Macro-micro tests of cohesive soil under varied normal and shear stresses subjected to drying-wetting cycles

open access: yesJournal of Rock Mechanics and Geotechnical Engineering
The mechanical behavior of cohesive soil is sensitized to drying-wetting cycles under confinements. However, the hydromechanical coupling effect has not been considered in current constitutive models.
Fangyue Luo, Ga Zhang, Yangping Yao
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

EFFECTS OF SAWING PATTERN ON DRYING RATE AND RESIDUAL DRYING STRESSES OF PINUS RADIATA LUMBER

open access: yesMaderas: Ciencia y Tecnología, 2002
Flatsawn and quartersawn Pinus radiata (radiata pine) sapwood boards were dried in a tunnel dryer in three runs using three drying schedules. These schedules represented low temperature (LT), accelerated conventional temperature (ACT) and high ...
S Pang, A.N Haslett
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

TECHNIQUES TO MONITOR DRYING STRESSES AND DIMENSIONAL CHANGES IN TIMBER FROM PLANTATION-GROWN EUCALYPTS FOR KILN SCHEDULE DEVELOPMENT AND KILN CONTROL

open access: yesMaderas: Ciencia y Tecnología, 2002
Drying tests were conducted with timber from 13 year-old plantation-grown Eucalyptus nitens and E. globulus, to determine shrinkage and drying degrade of tangential- and radial-sawn boards.
R.L. Northway
doaj  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Stiffening while drying

open access: yes, 2009
We present two models for the drying of waterborne paints, which consist of non-volatile latex particles suspended in water. One model considers the water and latex density in a layer as a function of time. Water evaporation at the surface represents the
Boettche, S   +2 more
core  

Soro de leite como agente encapsulante de Bifidobacterium BB-12 por spray drying [PDF]

open access: yes, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias. Programa de Pós-Graduação em Ciência dos Alimentos.O soro de leite e o principal subproduto da industria lactea.
Cislaghi, Fabiane Picinin de Castro
core  

Experimental investigation on the influence of drying on the seismic performance of three-story RC buildings

open access: yesDevelopments in the Built Environment
The drying of concrete has been recognized as a key phenomenon in the deterioration of concrete structures. Nevertheless, the complex conditions of real RC structures may lead to unforeseen responses observed from existing laboratory experiments on RC ...
Puttipong Srimook   +4 more
doaj   +1 more source

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