Results 71 to 80 of about 131,234 (264)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Control of Internal Moisture Transfer Direction and Lateral Moisturization to Mitigate Drying Defects in Large-Cross Section Timber

BioResources
Methods for surface moisturization and control of internal moisture movement have been developed to minimize moisture gradients and reduce drying defects, such as cracks, in large cross-sectional timbers used for restoring palaces, temples, and cultural ...
Bat-Uchral Batjargal, Taekyeong Lee, Chang-Jin Lee, Jung-Kwon Oh, Hwanmyeong Yeo   +4 more
doaj  

Effects of temporal salt accumulation during accelerated drying-wetting cycles on physical properties of cement mortars and determining of ocean salt crystallization pressure stress

Next Materials
Elucidating the degradation mechanism of inorganic materials in special service environments such as ocean environment has important scientific and engineering significance.
Jinbo Yang, Ze Zhang, Yu Zhang
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Computer Simulation of Drying Stresses in Wood

Journal of the Society of Materials Science, Japan, 1973
Computer simulation was conducted to assess the effect of the rate of drying on stress in wood during drying. Numerical calculations for the simulation were carried out with an electronic computer FACOM 270-20/30. Examples of the flow chart and FORTRAN programs used are shown in the text where we assumed that the stress follows the integro-differential
openaire   +2 more sources

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

A laboratory-based test procedure for the investigation of slaking-induced changes in geotechnical properties of tailing dam embankment materials

Heliyon
Slaking is a process of material parameters alteration resulting from wetting-drying cycles, changes in overburden stress, and chemical interactions. Tailings Storage Facilities (TSF) constructed with materials prone to slaking may experience breaches ...
Chaminda Gallage, Shiran Jayakody, Tharindu Abeykoon, Dareeju Biyanvilage, Jay Rajapakse   +4 more
doaj   +1 more source