Results 41 to 50 of about 350,942 (248)

Dual disorders or dual diagnosis?

Irish Journal of Psychological Medicine
Abstract “Dual disorders” (DD) refers to the co-occurrence of addiction and other mental health conditions, which often interact and complicate care. Despite scientific evidence showing shared brain mechanisms, current diagnostic systems treat them separately, leading to fragmented treatment and stigma.
Nestor Szerman, Lars Lien, Ruben Baler
openaire   +2 more sources

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Low-frequency transcranial magnetic stimulation is beneficial for enhancing synaptic plasticity in the aging brain

Neural Regeneration Research, 2015
In the aging brain, cognitive function gradually declines and causes a progressive reduction in the structural and functional plasticity of the hippocampus. Transcranial magnetic stimulation is an emerging and novel neurological and psychiatric tool used
Zhan-chi Zhang, Feng Luan, Chun-yan Xie, Dan-dan Geng, Yan-yong Wang, Jun Ma   +5 more
doaj   +1 more source

"Swallow Them All, and It's Just Like Smack": Comorbidity, Polypharmacy, and Imagining Moral Agency alongside Methadone and Antipsychotics

Medicine Anthropology Theory, 2023
This research article investigates moral agency in the spaces between the methadone clinic and the inpatient psychiatric ward by exploring the ways dually-diagnosed service users move though ever-more labyrinthine networks of care.
Michael D'Arcy
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The relationship between personality dimensions and addiction type in women addicted to alcohol and opioids

Scientific Reports
Personality traits significantly influence the development, persistence, and treatment outcomes of substance use disorders. Despite increasing addiction rates among women, sex-specific research remains limited.
Diana Raketić, Nikola Lalović, Jasmina Barišić, Ivan Ćelić, Srdjan Milovanović   +4 more
doaj   +1 more source

A multisite randomized controlled trial of Seeking Safety vs. Relapse Prevention Training for women with co-occurring posttraumatic stress disorder and substance use disorders

European Journal of Psychotraumatology, 2019
Background: Co-occurring posttraumatic stress disorder (PTSD) and substance use disorders (SUD) are associated with a more severe course and worse outcome than either disorder alone. In Europe, few treatments have been evaluated for PTSD and SUD. Seeking
Ingo Schäfer, Annett Lotzin, Philipp Hiller, Susanne Sehner, Martin Driessen, Thomas Hillemacher, Martin Schäfer, Norbert Scherbaum, Barbara Schneider, Johanna Grundmann   +9 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Childhood maltreatment trauma: a comparison between patients in treatment for substance use disorders and patients in mental health treatment

European Journal of Psychotraumatology, 2018
Background: While previous research has found strong associations between childhood maltreatment trauma and substance use disorders (SUDs), the role of possible moderating effects of gender and mediating effects of psychopathology and SUD is unclear ...
Ingvild S. Rasmussen, Kjersti Arefjord, Dagfinn Winje, Anders Dovran   +3 more
doaj   +1 more source