Results 61 to 70 of about 757,573 (291)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Low-frequency transcranial magnetic stimulation is beneficial for enhancing synaptic plasticity in the aging brain

Neural Regeneration Research, 2015
In the aging brain, cognitive function gradually declines and causes a progressive reduction in the structural and functional plasticity of the hippocampus. Transcranial magnetic stimulation is an emerging and novel neurological and psychiatric tool used
Zhan-chi Zhang, Feng Luan, Chun-yan Xie, Dan-dan Geng, Yan-yong Wang, Jun Ma   +5 more
doaj   +1 more source

An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor. [PDF]

, 2015
BackgroundWarthin tumors presenting concomitantly with a lymphoma is vanishingly rare with only 15 reported cases in English literature. Herein, we report an unusual initial presentation of a mantle cell lymphoma involving the lymphoid stroma of a ...
Arcega, Ramir S, Bhuta, Sunita, Blackwell, Keith E, Feinstein, Aaron J, Pullarkat, Sheeja T, Rao, Nagesh P   +5 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

The relationship between personality dimensions and addiction type in women addicted to alcohol and opioids

Scientific Reports
Personality traits significantly influence the development, persistence, and treatment outcomes of substance use disorders. Despite increasing addiction rates among women, sex-specific research remains limited.
Diana Raketić, Nikola Lalović, Jasmina Barišić, Ivan Ćelić, Srdjan Milovanović   +4 more
doaj   +1 more source

A multisite randomized controlled trial of Seeking Safety vs. Relapse Prevention Training for women with co-occurring posttraumatic stress disorder and substance use disorders

European Journal of Psychotraumatology, 2019
Background: Co-occurring posttraumatic stress disorder (PTSD) and substance use disorders (SUD) are associated with a more severe course and worse outcome than either disorder alone. In Europe, few treatments have been evaluated for PTSD and SUD. Seeking
Ingo Schäfer, Annett Lotzin, Philipp Hiller, Susanne Sehner, Martin Driessen, Thomas Hillemacher, Martin Schäfer, Norbert Scherbaum, Barbara Schneider, Johanna Grundmann   +9 more
doaj   +1 more source

Predicting costs of mental health care: a critical literature review [PDF]

, 2007
Cost evaluation research in the mental health field is being increasingly recognized as a way to achieve a more effective deployment of scarce resources.
Amaddeo, F., Barbui, C., Jones, J., Tansella, M.   +3 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Childhood maltreatment trauma: a comparison between patients in treatment for substance use disorders and patients in mental health treatment

European Journal of Psychotraumatology, 2018
Background: While previous research has found strong associations between childhood maltreatment trauma and substance use disorders (SUDs), the role of possible moderating effects of gender and mediating effects of psychopathology and SUD is unclear ...
Ingvild S. Rasmussen, Kjersti Arefjord, Dagfinn Winje, Anders Dovran   +3 more
doaj   +1 more source