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Addiction Science & Clinical PracticeBackground Knowledge of co-occurring mental disorders (termed ‘dual diagnosis’) among patients receiving opioid agonist treatment (OAT) is scarce. This study aimed (1) to estimate the prevalence and structure of dual diagnoses in two national cohorts of ...
Gabriela Rolová +4 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
The Effectiveness of Supported Employment in People With Dual Disorders
, 2011 OBJECTIVE: This study compared the effectiveness of the Individual Placement and Support (IPS) model of supported employment to control vocational rehabilitation programs for improving the competitive work outcomes of people with a severe mental illness ...
Robert E. Drake +5 more
core +1 more source
Treatment of patients with comorbidity of substance use disorder and psychotic disorder
Zdravniški Vestnik, 2010 The term dual diagnosis is used to describe the comorbid condition of substance use disorder and other mental disorder. The prevalence of substance use disorders is higher among patients with other mental disorders than in general population.
Nuša Šegrec, Andrej Kastelic
doaj
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
BMC ChemistryMood disorders affect the daily lives of millions of people worldwide. The search for more efficient therapies for mood disorders remains an active field of research.
Valeria V. Kleandrova +2 more
doaj +1 more source
The Impact of the COVID-19 Pandemic on the Severity of Alcohol Use Disorder: Significance of Dual Disorders. [PDF]
Int J Environ Res Public Health, 2023 Gajdics J +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Experimental Study of Dual Bell Nozzles [PDF]
, 2007 An experimental study was conducted testing Dual-bell nozzles in various conditions at DLR’s cold gas test stand. The stability of the nozzle flow has been verified by measuring the pressure ratio values by flow transition and retransition, to ensure a ...
Nürnberger-Génin, Chloé, Stark, Ralf
core
Dual Task Performance in Parkinson’s Disease
Behavioural Neurology, 2013 Several studies have found dual tasking to be impaired in Alzheimer's disease (AD), but unaffected by healthy ageing. It is not known if this deficit is specific to AD, or also present in other neurodegenerative disorders that can occur in later life ...
Jennifer A. Foley +2 more
doaj +1 more source