Results 121 to 130 of about 2,492,581 (284)

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Psychiatric disorders and mental health care among incarcerated men: A prerelease cross-sectional study in France

European Psychiatry
Background The mental health of incarcerated individuals is a widely recognized public health issue, but little is known about the mental health status of the incarcerated individuals upon release.
Thomas Fovet, Kevin D’Ovidio, Marion Eck, Imane Benradia, Stéphane Duhem, Camille Lancelevée, Pierre Thomas, Marielle Wathelet, Ali Amad   +8 more
doaj   +1 more source

Sexual Differences in Addictions and Dual Disorders: Importance of Gender Perspective. [PDF]

Brain Sci, 2022
Benito A, Rodríguez de Fonseca F, Haro G.   +2 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Nationwide study of emergency care quality for patients with substance use disorders and dual diagnoses across three distinct patient populations

BMC Psychiatry
Background Substance use disorders and mental illness increase morbidity and mortality, particularly among patients with coexisting mental illness and substance use (dual diagnoses). This study evaluated the quality of prehospital care (Emergency Medical
Julie Mackenhauer, Mette Marie Berg, Søren Valgreen Knudsen, Erika F. Christensen, Jan Mainz, Søren Paaske Johnsen   +5 more
doaj   +1 more source

Effects of Neurological Disorders on Health Expenditure and Economic Output: Dynamic Panel Analysis for OECD Countries

Systems
Analyzing the prevalence of neurological disorders (NDs) is crucial to understand health expenditures and economic outcomes as they change over time and have significant economic effects.
Salim Yılmaz, Canser Boz, Salih Haluk Özsarı, Faruk Yılmaz, Buse Fidan Türkön, Anı Hande Mete   +5 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

The clinical significance of an AI-based assumption model for neurocognitive diseases using a novel dual-task system

Scientific Reports
Dual-task composed of gait or stepping tasks combined with cognitive tasks has been well-established as valuable tools for detecting neurocognitive disorders such as mild cognitive impairment and early-stage Alzheimer’s disease. We previously developed a
Yuto Satake, Daiki Taomoto, Shuqiong Wu, Ákos Godó, Shunsuke Sato, Maki Suzuki, Fumio Okura, Yasushi Yagi, Manabu Ikeda   +8 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source