Results 31 to 40 of about 1,154,940 (248)

Dual malignancies in Lynch Syndrome: A rare case of synchronous colorectal and ovarian cancer highlighting the potential role of immunotherapy

Journal of Clinical and Health Sciences
We report a 35-year-old woman with dual malignancies associated with Lynch Syndrome, diagnosed with Stage IIIC sigmoid colon adenocarcinoma and Stage IIA left ovarian serous papillary adenocarcinoma.
Ng Kai Jian, Mohammad Qisti Khairi Mohammad Rizzuan, Low Qin Jian   +2 more
doaj   +1 more source

Model of Care for People with Mental Disorder and Co-existing Substance Use Disorder (Dual Diagnosis)

, 2023
This Model of Care has been developed in partnership with HSE Social Inclusion, HSE Health and Wellbeing and the National Office of Suicide Prevention and in collaboration with voluntary bodies including Sec.39 agencies.
National Working Group for Dual Diagnosis
core  

Pattern of occurrence and treatment outcome of second primary malignancies: A single center experience

South Asian Journal of Cancer, 2017
Background: The incidence of cancer survivors is increasing, but these individuals, unfortunately, face the risk of second primary malignancies (SPMs).
Prekshi Chaudhary, Sweety Gupta, Nitin Leekha, Ruchir Tandon, Malay Nandy, Sudarsan De   +5 more
doaj   +1 more source

Metachronous occurrence of acute myeloid leukaemia in a case of neuroendocrine tumour

European Journal of Case Reports in Internal Medicine
Haematological neoplasms are rare in patients undergoing peptide receptor radionuclide therapy (PRRT) for neuroendocrine neoplasms, though the long-term effects on bone marrow function remain an area of interest.
Abhinav Menon, Dilip Harindran Vallathol, Deepak Charles, Shagos Nair, Karthika Kundil Veetil, Ashok S. Komaranchath, Arun R. Warrier   +6 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Construction of CD19 targeted dual- and enhanced dual-antibodies and their efficiency in the treatment of B cell malignancy

Experimental Hematology & Oncology, 2023
Background T cell-redirecting bispecific antibodies establish a connection between endogenous T cells and tumor cells, activating T cells function to eliminate tumor cells without ex vivo genetic alteration or manipulation.
Manling Chen, Xiaoyu Liu, Nan Peng, Ting Zhang, Junli Mou, Huizhen He, Ying Wang, Yingxi Xu, Haiyan Xing, Kejing Tang, Zheng Tian, Qing Rao, Runxia Gu, Shaowei Qiu, Min Wang, Jianxiang Wang   +15 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source