Results 51 to 60 of about 1,154,940 (248)

Malignancy within a Tail Gut Cyst: A Case of Retrorectal Carcinoid Tumour [PDF]

, 2014
Purpose. Tailgut cysts with malignant transformation are rare entities. We discuss the diagnostic strategy and treatment of a malignancy within a tailgut cyst. Methods.
Abukar, AA, Steele, RJC, R. J. C. Steele, P. V. Patil, Abukar, A. A., A. A. Abukar, Patil, P. V., THAHA, MA, C. B. Lim, Lim, C. B., Ramsanahie, A., Carey, F, A. Ramsanahie, M. A. Thaha, Steele, R. J. C., Thaha, M. A., Ramsanahie, A, B. J. Parcell, F. Carey, Lim, CB, Patil, PV, Parcell, B. J.; id_orcid, Carey, F., Parcell, BJ   +23 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 kinase
Min-Wu Chao, Tony Eight Lin, Wei-Chun HuangFu, Chao-Di Chang, Huang-Ju Tu, Liang-Chieh Chen, Shih-Chung Yen, Tzu-Ying Sung, Wei-Jan Huang, Chia-Ron Yang, Shiow-Lin Pan, Kai-Cheng Hsu   +11 more
doaj   +1 more source

Dual-Band Tunable Recursive Active Filter [PDF]

, 2011
This letter presents a novel recursive active filter topology that provides dual-band performance, with independent tuning capability in both bands. The dual-band operation is achieved by using two independent feedback lines.
García Pérez, Oscar Alberto, Aznar Ballesta, Francisco, Daniel Segovia-Vargas, Vicente Gonzalez-Posadas, Francisco Aznar-Ballesta, Segovia Vargas, Daniel, Oscar Garcia-Perez, González Posadas, Vicente   +7 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

An unusual case of hepatic lymphoma with multiple epithelial malignancies

Indian Journal of Pathology and Microbiology, 2018
Primary hepatic mucosa-associated lymphoid tissue lymphoma (MALToma) is a rare entity. Its coexistence with other malignancies is even rarer. Only few case reports of its association with other malignancies mostly gastric and colon cancer have been ...
Anuj Khurana, Urmi Mukherjee, Nayana Patil   +2 more
doaj   +1 more source

Dual citizenship as a path-dependent process [PDF]

, 2004
Faist T, Gerdes J, Rieple B. Dual citizenship as a path-dependent process. COMCAD Arbeitspapiere - working papers, 7.
Gerdes, Jürgen, Thomas Faist, Rieple, Beate, Faist, Thomas, Jürgen Gerdes, Beate Rieple   +5 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Dual-band dual-beam millimeter-wave antenna using dual circular microstrip rings

The growing demand for high-capacity millimeter-wave (mmWave) communication systems requires compact, high-gain antennas that provide efficient spatial coverage while remaining simple to fabricate and integrate.
Chinthana Panagamuwa (1258632), Amitkumar Patel (15196726), William Whittow (1224405)   +2 more
core   +4 more sources

Expression Profile of Tyrosine Phosphatases in HER2 Breast Cancer Cells and Tumors

Cellular Oncology, 2010
Background: HER2-overexpression promotes malignancy by modulating signalling molecules, which include PTPs/DSPs (protein tyrosine and dual-specificity phosphatases). Our aim was to identify PTPs/DSPs displaying HER2-associated expression alterations.
Maria Antonietta Lucci, Rosaria Orlandi, Tiziana Triulzi, Elda Tagliabue, Andrea Balsari, Emma Villa-Moruzzi   +5 more
doaj   +1 more source