Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Dual Active Galactic Nuclei: Precursors of Binary Supermassive Black Hole Formation and Mergers
The Astrophysical JournalThe presence of dual active galactic nuclei (AGNs) on scales of a few tens of kiloparsecs can be used to study merger-induced accretion on supermassive black holes (SMBHs) and offer insights about SMBH mergers, using dual AGNs as merger precursors.
Vida Saeedzadeh +5 more
doaj +1 more source
Numerical Investigation in the Effect of Number of Nozzle Hole on Performance and Emission in Dual Fuel Engine [PDF]
, 2013 Jafari, Domiri Ganji
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In situ analysis of FGFR2 mRNA and comparison with FGFR2 gene copy number by dual-color in situ hybridization in a large cohort of gastric cancer patients [PDF]
, 2017 Yasutoshi Kuboki +9 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
A pore scale study on fluid flow through two dimensional dual scale porous media with small number of intraparticle pores [PDF]
, 2016 Safa Sabet +2 more
openalex +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Acceleration of Primal-Dual Methods by Preconditioning and Fixed Number of Inner Loops [PDF]
, 2018 Liu Yan-li, Yunbei Xu, Wotao Yin
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