Results 111 to 120 of about 10,739 (275)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A Tangible Solution for Hand Motion Tracking in Clinical Applications
Sensors, 2019 Objective real-time assessment of hand motion is crucial in many clinical applications including technically-assisted physical rehabilitation of the upper extremity.
Christina Salchow-Hömmen +5 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
IEEE AccessThis article addresses the challenge of modeling and controlling load-assist exoskeletons operating under dynamic and uncertain conditions. Traditional approaches often rely solely on dual quaternions for kinematic modeling, limiting their applicability ...
Angel Eduardo Zamora-Suarez +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Relative Motion Dynamics Modeling and Control of DFP Vibration Isolation Spacecraft
Xibei Gongye Daxue Xuebao, 2019 In order to better meet the future high precision task requirements, the DFP(Disturbance-Free Payload) spacecraft composed of non-contact PM(Payload Module)and SM(Support Module)is taken as the object to study the relative motion dynamics modeling and ...
doaj +1 more source
Generalized dual Fibonacci quaternions with dual coefficient [PDF]
Notes on Number Theory and Discrete Mathematics, 2018 In this paper, we defined the generalized dual Fibonacci quaternions with dual coefficient. Also, we investigated the relations between the generalized dual Fibonacci quaternions with dual coefficient. Furthermore, we gave the Binet's formulas and Cassini identities for these quaternions.
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source