Results 51 to 60 of about 149,447 (303)
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Redukcje świadomości i problem trzeciej drogi (Reductions of consciousness and the problem of a third way) [PDF]
Analiza i Egzystencja, 2010 The leading idea of the article is defined by a quotation from Fichte concerning the opposition between idealism and “dogmatism”, or naturalism. That opposition is interpreted as a result of two alternative “reductions of consciousness”: according to the
Małgorzata Kowalska
doaj
The Role of Necessity in Facing the Problem of Evil in Plato's Philosophy [PDF]
پژوهشنامه فلسفه دین, 2018 Plato, when dealing with the problem of evil, more than anything, tries to keep the good and the ideas transcendent and uninvolved in evil. Therefore, apart from the fact that he recognizes humans as the cause of some evil, he talks of a concept called ...
Mohammad Firuzkuhy +1 more
doaj +1 more source
THE SUBSTANCE-ATTRIBUTES RELATIONSHIP IN CARTESIAN DUALISM [PDF]
, 2018 In their book on Descartes’s changing mind, Peter Machamer and J.E McGuire argue that Descartes discarded dualism to embrace a kind of monism. It is intriguing to investigate if the master of dualism could have changed his mind about the central aspect ...
Monnoyeur, Francoise
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Keeping it Real: Encountering Mixed Reality in igloo’s SwanQuake: House
, 2012 This paper employs the writings of early twentieth-century phenomenologists to examine physical/virtual dualism a century later. It considers the nature of embodied experience in mixed reality environments through an analysis of the author’s encounter ...
Popat, SH
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Judicial Defence of Constitutionalism in the Assessment of South Africa's International Obligations
Potchefstroom Electronic Law Journal, 2019 The (sometimes fragile) balance between South Africa's constitutional obligations to protect and promote human rights in the international arena and the realities of political practice is the focus of this paper.
Francois Venter
doaj +1 more source