Results 61 to 70 of about 924 (199)

Prospective role of cefiderocol in the management of carbapenem-resistant Acinetobacter baumannii infections: Review of the evidence [PDF]

, 2023
Carbapenem-resistant Acinetobacter baumannii (CRAB) has been classified by the World Health Organization as being in the critical category of pathogens requiring urgent new antibiotic treatment options.
Dupont, Herve, Echols, Roger, Greenberg, David E, Kollef, Marin, Nicolau, David P, Viale, Pierluigi, Yamano, Yoshinori   +6 more
core   +3 more sources

Durlobactam in combination with β-lactams to combat Mycobacterium abscessus

Antimicrobial Agents and Chemotherapy
ABSTRACT Mycobacterium abscessus ( Mab ) presents significant clinical challenges. This study evaluated the synergistic effects of a β-lactam and β-lactamase inhibitor combination against Mab and explored the underlying mechanisms ...
Eunjeong Shin, Khalid M. Dousa, Magdalena A. Taracila, Christopher R. Bethel, Mary Nantongo, David C. Nguyen, Chidiebere Akusobi, Sebastian G. Kurz, Mark S. Plummer, Charles L. Daley, Steven M. Holland, Eric J. Rubin, Jürgen B. Bulitta, W. Henry Boom, Barry N. Kreiswirth, Robert A. Bonomo   +15 more
openaire   +2 more sources

Protein Spatial Structure Meets Artificial Intelligence: Revolutionizing Drug Synergy–Antagonism in Precision Medicine

Advanced Science, Volume 12, Issue 33, September 4, 2025.
This review comprehensively examines the applications of protein three‐dimensional structures and artificial intelligence in investigating drug synergistic and antagonistic effects. The research findings provide compelling evidence for the precision treatment of cancer and metabolic diseases, thereby promoting the development of personalized medicine ...
Anqi Lin, Chang Che, Aimin Jiang, Chang Qi, Antonino Glaviano, Zhijie Zhao, Zhirou Zhang, Zaoqu Liu, Ziyao Zhou, Quan Cheng, Shuofeng Yuan, Peng Luo   +11 more
wiley   +1 more source

Flexible Development Programs for Antibacterial Drugs to Address Unmet Medical Needs

Emerging Infectious Diseases
The US Food and Drug Administration recognizes the unmet medical need for antibacterial drugs to treat serious bacterial diseases caused by resistant pathogens for which effective therapies are limited or lacking.
Mayurika Ghosh, Dmitri Iarikov, Xiaojing (Karen) Qi, Daniel Rubin, Simone Shurland, Avery Goodwin, Xiaohui Wei, Dakshina Chilukuri, Owen McMaster, Terry Miller, Peter Kim, Adam Sherwat   +11 more
doaj   +1 more source

Treatment of infections caused by carbapenem-resistant Acinetobacter baumannii

Frontiers in Cellular and Infection Microbiology
Patients with severe carbapenem-resistant Acinetobacter baumannii (CRAB) infections currently face significant treatment challenges. When patients display signs of infection and the clinical suspicion of CRAB infections is high, appropriate treatment ...
Siqin Zhang, Lingfang Di, Yan Qi, Xiang Qian, Siwei Wang   +4 more
doaj   +1 more source

Acinetobacter baumannii in the critically ill: complex infections get complicated [PDF]

, 2023
Acinetobacter baumannii is increasingly associated with various epidemics, representing a serious concern due to the broad level of antimicrobial resistance and clinical manifestations. During the last decades, A.
Cavallo I., Di Domenico E. G., Fabrizio G., Oliva A., Pages R., Pasqua M., Pimpinelli F., Sivori F., Truglio M.   +8 more
core   +1 more source

Pharmacokinetics of continuous infusion ceftolozane/tazobactam in two patients with extensive total body surface area burns

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 6, Page 386-392, June 2025.
Abstract Introduction Treatment of infections in patients with burn injuries is challenging due to altered antimicrobial pharmacokinetics. Continuous infusion β‐lactam therapy may be a useful antimicrobial stewardship strategy to improve pharmacodynamic target attainment in this population.
Jay D. Olivet, Megan Amerson‐Brown, Juan J. Calix, Emma Graffice, Tyson Kilpatrick, Hanna F. Roenfanz, David P. Nicolau, Joseph L. Kuti, Matthew L. Brown   +8 more
wiley   +1 more source

Antimicrobial resistance:a concise update [PDF]

Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately 5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted and cohesive approach that ranges from increased understanding of ...
Aung, Thet Tun, de la Fuente-Nunez, Cesar, Hancock, Robert E W, Ho, Charlotte S, Kintses, Balint, Lakshminarayanan, Rajamani, McNally, Alan, Mehta, Jodhbir S, Peacock, Sharon J, Rauz, Saaeha, Ting, Darren S J, Wong, Carlos T H   +11 more
core   +2 more sources

A review of antibiotic safety in pregnancy—2025 update

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 4, Page 227-237, April 2025.
Abstract Antibiotics constitute the majority of prescriptions for women during pregnancy. Common bacterial infections, including urinary tract infections, skin and soft tissue infections, and upper and lower respiratory tract infections, are expected in pregnancy, similar to the general public.
Johny Nguyen, Victoria Madonia, Christopher M. Bland, Kayla R. Stover, Lea S. Eiland, Julia Keating, Madeline Lemmon, P. Brandon Bookstaver, as part of the Southeastern Research Group Endeavor (SERGE‐45) research network   +8 more
wiley   +1 more source

Antimicrobial activity of sulbactam-durlobactam against Acinetobacter baumannii-calcoaceticus complex strains causing non-respiratory and non-bloodstream infections from the United States (2023–2025)

Microbiology Spectrum
Acinetobacter baumannii most often causes pneumonia in critically ill patients. However, A. baumannii is also an important cause of a broader range of infections, including skin/wound and urinary tract infections. This study aims to evaluate the in vitro
Elizabeth Cyr, Jill Argotsinger, Eric T. Beck, Robin R. Chamberland, Andrew E. Clark, Anne R. Daniels, Rachael Liesman, Mark Fisher, Philip Gialanella, Jonathan Hand, Amanda T. Harrington, Romney M. Humphries, Holly Huse, Robert Hamilton-Seth, Julia D. Hankins, Wesley D. Kufel, Scott W. Riddell, Meera Mehta, Ryan Demkowicz, A. Brian Mochon, Hossein Salimnia, Ayesha Khan, Virginia M. Pierce, Raghava Potula, Tsigereda Tekle, Patricia J. Simner, Robert J. Tibbetts, Christine Vu, Lilian M. Abbo, Octavio Martinez, Rebekah E. Dumm, Manohar B. Mutnal, Timothy C. Jenkins, Violeta Chávez, Paulette Pinargote, Jennifer Bowling, Erik Munson, Daniel V. Zurawski, David P. Nicolau, Tomefa E. Asempa   +39 more
doaj   +1 more source