In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals [PDF]
The activity of a novel β-lactamase inhibitor combination, sulbactam-durlobactam (SUL-DUR), was tested against 87 colistin-resistant and/or cefiderocol-non-susceptible carbapenem-resistant Acinetobacter baumannii clinical isolates collected from U.S ...
Cober, Eric +14 more
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Nephrotoxicity of New Antibiotics: A Systematic Review [PDF]
Drug-induced nephrotoxicity is a common and serious problem in clinical practice. We conducted a systematic review of studies reporting nephrotoxicity events associated with antibiotics approved since 2018.
Laura T. Romanos +3 more
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New Drugs, Old Problems: A Narrative Review of Antibiotic Stewardship Program in the era of novel Gram-negative antibiotics [PDF]
Background: The global spread of multidrug-resistant (MDR) Gram-negative bacteria has led to the introduction of several novel antibiotics. However, emerging resistance threatens their long-term utility, emphasizing the importance of antimicrobial ...
Elena, Carrara +2 more
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Recent updates in treating carbapenem-resistant infections in patients with hematological malignancies [PDF]
IntroductionPatients with hematological malignancies (PHMs) are at increased risk for infections caused by carbapenem-resistant organisms (CROs) due to frequent exposure to broad-spectrum antibiotics and prolonged hospital stays.
Aslan, Abdullah Tarik, AKOVA, MURAT
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Current treatment options for pneumonia caused by carbapenem-resistant Acinetobacter baumannii [PDF]
PURPOSE OF REVIEW: The purpose of this review is to briefly summarize the challenges associated with the treatment of pneumonia caused by carbapenem-resistant Acinetobacter baumannii (CRAB), discuss its carbapenem-resistance, and review the literature ...
Franzone, John P. +2 more
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Antimicrobial Agents and ChemotherapyABSTRACT β-Lactams present several desirable pharmacodynamic features leading to the rapid eradication of many bacterial pathogens. Imipenem (IPM) and cefoxitin (FOX) are injectable β-lactams recommended during the intensive treatment phase of pulmonary infections caused by Mycobacterium ...
Dereje A. Negatu +8 more
openaire +2 more sources
β-Lactam/β-Lactamase Inhibitor Combination Antibiotics Under Development [PDF]
Antimicrobial resistance remains a public health problem of global concern with a great health and financial burden. Its recognition as a threat by political leadership has boosted the research and development of new antibiotics and particularly novel ...
Christina-Maria Asimotou +4 more
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Journal of Global Antimicrobial ResistanceThis study aimed to investigate sulbactam-durlobactam (SUL-DUR) susceptibility and molecular features of carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from a Shenzhen teaching hospital.A retrospective study on CRAB was conducted from January 2018 to June 2025.
Hanlian Huang +7 more
openaire +2 more sources
Treatment Strategies of Colistin Resistance Acinetobacter baumannii Infections [PDF]
Acinetobacter baumannii has emerged as a pressing challenge in clinical practice, mainly due to the development of resistance to multiple antibiotics, including colistin, one of the last-resort treatments.
Stamatis Karakonstantis +5 more
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COMBINATORIAL THERAPEUTIC STRATEGIES TO COMBAT MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII [PDF]
Acinetobacter baumannii is an opportunistic Gram-negative pathogen that poses a significant global health threat due to its remarkable ability to acquire multidrug (MDR) and extensively drug-resistant (XDR) phenotypes.
Aderibigbe, Tope A
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