Results 61 to 70 of about 1,113,255 (292)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dust production scenarios in galaxies at z ~ 6-8.3

, 2019
The mechanism of dust formation in galaxies at high redshift is still unknown. Asymptotic giant branch (AGB) stars and explosions of supernovae (SNe) are possible dust producers, and non-stellar processes may substantially contribute to dust production ...
Leśniewska, A., Michałowski, M. J.
core   +1 more source

Nonlinear Evolution of Instabilities Between Dust and Sound Waves [PDF]

, 2018
We study the non-linear evolution of the acoustic 'Resonant Drag Instability' (RDI) using numerical simulations. The acoustic RDI is excited in a dust-gas mixture when dust grains stream through gas, interacting with sound waves to cause a linear ...
Hopkins, Philip F., Moseley, Eric R., Squire, Jonathan   +2 more
core   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Infrared Emission from Supernova Remnants: Formation and Destruction of Dust

, 2017
We review the observations of dust emission in supernova rem- nants (SNRs) and supernovae (SNe). Theoretical calculations suggest that SNe, particularly core-collapse, should make significant quantities of dust, perhaps as much as a solar mass ...
A Sarangi, AP Jones, B Ercolano, BB Ochsendorf, BE Sugerman, BJ Williams, BJ Williams, BJ Williams, BT Draine, BT Draine, C Gall, E Dwek, E Dwek, E Dwek, HL Gomez, HL Gomez, J Fabbri, JD Slavin, KJ Borkowski, M Elvis, M Lakicevic, M Matsuura, MJ Barlow, N Smith, P Bouchet, PJ Owen, R Indebetouw, R Kotak, R Sankrit, R Wesson, RD Gehrz, RG Arendt, RG Arendt, RM Lau, SH Moseley, T Kozasa, T Nozawa, T Nozawa, T Szalai, T Temim, T Temim, T Temim, WP Blair, WPS Meikle, WT Reach   +44 more
core   +1 more source

Characterization of dust activity on Mars from MY27 to MY32 by PFS-MEX observations [PDF]

, 2018
We present spatial and temporal distributions of dust on Mars from Ls = 331 in MY26 until Ls = 80 in MY33 retrieved from the measurements taken by the Planetary Fourier Spectrometer (PFS) aboard Mars Express.
Aoki, Shohei, Aronica, Alessandro, Giuranna, Marco, Grassi, Davide, Saggin, Bortolino, Scaccabarozzi, Diego, Wolkenberg, Paulina   +6 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Prediction of heterogeneous nucleation condensation effect on the surface of respiratory coal dust and test of dust reduction test

Meitan xuebao
Surface wettability of coal dust particles is an important factor restricting the efficiency of wet dust removal. Heterogeneous nucleation condensation on the surface of coal dust particles is a means without any pollution, without considering the ...
Hanyi LIN, Liang YUAN, Bingyou JIANG, Yuqian ZHANG, Yifan WANG, Haoyu WANG   +5 more
doaj   +1 more source

A Model Connecting Galaxy Masses, Star Formation Rates, and Dust Temperatures Across Cosmic Time

, 2018
We investigate the evolution of dust content in galaxies from redshifts z=0 to z=9.5. Using empirically motivated prescriptions, we model galactic-scale properties -- including halo mass, stellar mass, star formation rate, gas mass, and metallicity -- to
Behroozi, Peter, Conroy, Charlie, Imara, Nia, Johnson, Benjamin D., Loeb, Abraham   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source