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The contrasting roles of water and dust in controlling daily variations in radiative heating of the summertime Saharan heat low [PDF]
, 2016 The summertime Sahara heat low (SHL) is a key component of the West African monsoon (WAM) system. Considerable uncertainty remains over the relative roles of water vapour and dust aerosols in controlling the radiation budget over the Sahara and therefore
A. J. Roberts +8 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Case Studies in Thermal Engineering, 2023 Workers in deep coal mines are often exposed to hyperthermal conditions, which is a health and safety hazard. Although many novel approaches have been proposed in recent years, air distribution optimization combined with thermal analysis based on ...
Tianyang Wang +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
ToxicsSilicosis is an irreversible and progressive pulmonary fibrotic disease caused by the long-term inhalation of silica dust. The precise molecular mechanisms underlying the disease remain incompletely understood, and effective early diagnostic biomarkers ...
Jia Wang +4 more
doaj +1 more source
BioResources, 2016 The interaction among three biomass components (hemicellulose, cellulose, and lignin) in an autoclave was studied based on the extreme vertices of a constrained region that had a significant effect on the distribution and characteristics of the products.
Ying Gao +7 more
doaj +1 more source
Case Studies in Thermal Engineering, 2022 During the construction of tunnels subjected to high temperatures (here called high-temperature tunnels), ventilation cooling is an essential requirement. A high-temperature section of a construction tunnel on the Sichuan-Tibet Railway was used as a test
Guoliang Zhang +4 more
doaj +1 more source
, 2012 Merger processes play an important role in galaxy formation and evolution. To study the influence of merger processes on the evolution of dust properties and cosmic star formation rate, we investigate a local sample of major merger galaxies and a control
Buat, V. +5 more
core +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The color excess of quasars with intervening DLA systems- Analysis of the SDSS data release five
, 2007 We analyzed the spectroscopic and photometric database of the 5th data release of the Sloan Digital Sky Survey (SDSS) to search for evidence of the quasar reddening produced by dust embedded in intervening damped Ly alpha (DLA) systems.
A. M. Wolfe +69 more
core +1 more source