Results 61 to 70 of about 611,299 (306)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Relationship between occupational stress and occupational injury of workers in a cable manufacturing enterprise by decision tree model

环境与职业医学
BackgroundSocial psychological factors have emerged as a key area of research in occupational injury prevention. Occupational stress, a significant component of social psychology, has garnered widespread attention due to its potential impact on ...
Ting XU, Juan QIAN, Yishuo GU, Daozheng DING, Jianjian QIAO, Yong QIAN, Xiaojun ZHU, Jingguang FAN   +7 more
doaj   +1 more source

Screening for the Interaction of Diabetes Mellitus and Other Factors in Tuberculosis

Iranian Journal of Public Health, 2019
No Abstract No Abstract No ...
Min MU, Jing WU, Jian-Hua WANG, Xin-Rong TAO, Dong HU, Kai LIU, Ke-Hong FANG, Song XUE, Jie SHANG   +8 more
doaj   +1 more source

A New Quantitative Method for Risk Assessment of Coal Floor Water Inrush Based on PSR Theory and Extension Cloud Model

Geofluids, 2021
In order to scientifically and reasonably assess the risk of water inrush from the coal seam floor, considering the influence of natural environmental factors such as hydrogeology, mining, and human intervention, the PSR model of ecosystem health ...
Bingyou Jiang, Bo Ren, Mingqing Su, Bao Wang, Xin Li, Guofeng Yu, Tingshuang Wei, Yunchun Han   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Efficient ortho-para conversion of H2 on interstellar grain surfaces

, 2016
Context: Fast surface conversion between ortho- and para-H2 has been observed in laboratory studies, and this mechanism has been proposed to play a role in the control of the ortho-para ratio in the interstellar medium.
Bourlot, Jacques Le, Bron, Emeric, Petit, Franck Le   +2 more
core   +2 more sources

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Epidemiological trends of lung cancer attributed to residential radon exposure at global, regional, and national level: a trend analysis study from 1990 to 2021

Frontiers in Public Health
BackgroundLung cancer (LC) remains a leading cause of cancer-related mortality globally, with radon identified as the second major risk factor. This study aimed to analyze the global, regional, and national burden of LC attributed to residential radon ...
Qiang Xiong, Qiang Xiong, Zhen Zhang, Zhen Zhang, Jianliang Peng, Jianliang Peng, Jing Liang, Jing Liang, Dexing Lian, Dexing Lian, Xipeng Zhao, Xipeng Zhao, Lulu Wang, Lulu Wang, Tiangxiang Lu, Tiangxiang Lu, Yuwen Li, Yuwen Li   +17 more
doaj   +1 more source

Numerical Simulations of Turbulent Molecular Clouds Regulated by Reprocessed Radiation Feedback from Nascent Super Star Clusters

, 2015
Radiation feedback from young star clusters embedded in giant molecular clouds (GMCs) is believed to be important to the control of star formation.
Ostriker, Eve C., Skinner, M. Aaron
core   +1 more source