Results 61 to 70 of about 614,790 (357)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Characteristics and influencing factors of occupational injuries among workers in a cable manufacturing enterprise

环境与职业医学
BackgroundWorkers in the cable manufacturing industry are exposed to high-speed machinery and equipment for a long time, coupled with heavy workload, which poses significant risks to their physical health.
Ting XU, Juan QIAN, Yishuo GU, Daozheng DING, Jianjian QIAO, Yong QIAN, Xiaojun ZHU, Jingguang FAN   +7 more
doaj   +1 more source

Radiative impact of mineral dust on monsoon precipitation variability over West Africa [PDF]

, 2011
The radiative forcing of dust and its impact on precipitation over the West Africa monsoon (WAM) region is simulated using a coupled meteorology and aerosol/chemistry model (WRF-Chem).
Hagos, S., Hagos, S., Leung, L. R., Leung, L. R., Liu, Xiaohong, Liu, Xiaohong, Zhao, C., Zhao, C.   +7 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Relationship between occupational stress and occupational injury of workers in a cable manufacturing enterprise by decision tree model

环境与职业医学
BackgroundSocial psychological factors have emerged as a key area of research in occupational injury prevention. Occupational stress, a significant component of social psychology, has garnered widespread attention due to its potential impact on ...
Ting XU, Juan QIAN, Yishuo GU, Daozheng DING, Jianjian QIAO, Yong QIAN, Xiaojun ZHU, Jingguang FAN   +7 more
doaj   +1 more source

Screening for the Interaction of Diabetes Mellitus and Other Factors in Tuberculosis

Iranian Journal of Public Health, 2019
No Abstract No Abstract No ...
Min MU, Jing WU, Jian-Hua WANG, Xin-Rong TAO, Dong HU, Kai LIU, Ke-Hong FANG, Song XUE, Jie SHANG   +8 more
doaj   +1 more source

A New Quantitative Method for Risk Assessment of Coal Floor Water Inrush Based on PSR Theory and Extension Cloud Model

Geofluids, 2021
In order to scientifically and reasonably assess the risk of water inrush from the coal seam floor, considering the influence of natural environmental factors such as hydrogeology, mining, and human intervention, the PSR model of ecosystem health ...
Bingyou Jiang, Bo Ren, Mingqing Su, Bao Wang, Xin Li, Guofeng Yu, Tingshuang Wei, Yunchun Han   +7 more
doaj   +1 more source

Numerical Simulations of Turbulent Molecular Clouds Regulated by Reprocessed Radiation Feedback from Nascent Super Star Clusters

, 2015
Radiation feedback from young star clusters embedded in giant molecular clouds (GMCs) is believed to be important to the control of star formation.
Ostriker, Eve C., Skinner, M. Aaron
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Best practices for dust control in coal mining, second edition. [PDF]

, 2021
James P. Rider, Jeffrey M. Listak, John A. Organiscak, Anita L. Wolfe, Jay F. Colinet, Cara N. Halldin, Joseph J. Schall, K Almberg, C Halldin, D Blackley, A Laney, E Storey, C Rose, Lht Go, R Cohen, V Antao, E Petsonk, L Sokolow, A Wolfe, G Pinheiro, J Hale, M Attfield, R Cohen, E Petsonk, C Rose, B Young, M Regier, A Najmuddin, J Abraham, A Churg, Fhy Green, J Colinet, M Harris, K Cashdollar, C Man, E Thimons, K Almberg, C Halldin, D Blackley, A Laney, E Storey, C Rose, Lht Go, R Cohen, K Almberg, L Friedman, C Rose, Lht Go, R Cohen, V Antao, E Petsonk, L Sokolow, Wolfe Al, G Pinheiro, J Hale, M Attfield, D Blackley, C Halldin, K Cummings, A Laney, D Blackley, C Halldin, A Laney, D Blackley, L Reynolds, C Short, N Hall, D Blackley, C Halldin, A Laney, N Hall, D Blackley, C Halldin, A Laney, C Halldin, W Reed, G Joy, J Colinet, J Rider, E Petsonk, J Abraham, A Wolfe, E Storey, A Laney, P Heaney, P Hessel, G Sluis-Cremer, E Hnizdo, M Faure, R Thomas, F Wiles, E Hnizdo, G Sluis-Cremer, G Joy, K Kreiss, B Zhen, B Miller, S Hagen, R Love, C Soutar   +99 more
openalex   +1 more source