Results 201 to 210 of about 10,339 (261)

Microblasting Wound Dressings Mechanically Disrupt Polymicrobial Biofilms to Enhance Healing in Treatment‐Resistant Wounds

Advanced Science, EarlyView.
Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn, Joo Hun Lee, Christian Hurd, Jiye Lee, Junggeon Park, Adam A. Markowicz, Zheyuan Zhang, Joanne Hwang, Guillermo L. Monroy, Simon A. Rogers, Woonggyu Jung, Stephen A. Boppart, Hyunjoon Kong   +12 more
wiley   +1 more source

A global decline in atmospheric dust during the 21st century

Gupta A, Kok J, Amiridis V, Gkikas A, Rizos K, Proestakis E, Logothetis S, Marinou E, García-Pando CP.   +8 more
europepmc   +1 more source

Extreme properties of a compact and massive accreting black hole host in the first 500 Myr. [PDF]

Nat Commun
Tripodi R, Martis N, Markov V, Bradač M, Di Mascia F, Cammelli V, D'Eugenio F, Willott C, Curti M, Bhatt M, Gallerani S, Rihtaršič G, Singh J, Gaspar G, Harshan A, Judež J, Merida RM, Desprez G, Sawicki M, Goovaerts I, Muzzin A, Noirot G, Sarrouh GTE, Abraham R, Asada Y, Brammer G, Estrada-Carpenter V, Felicioni G, Fujimoto S, Iyer K, Mowla L, Strait V.   +31 more
europepmc   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Evaluation of real-time source apportionment approaches in six Chinese cities using the AXA (ACSM, Xact, Aethalometer) instrumental set-up. [PDF]

Sci Rep
Manousakas MI, Cui T, Wang Q, Qi L, Furger M, Cheung RKY, Dada L, Hao Y, Khare P, Tian J, Han Y, Chen Y, Kong S, Wu Y, Sun Y, Zhang R, Slowik JG, Cao J, Daellenbach KR, Prévôt ASH.   +19 more
europepmc   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

From observation to protection a bibliometric analysis of aerosol-glacier interactions. [PDF]

iScience
Meng H, Wang F, Liu S, Jin X, Xu M, Mu J.   +5 more
europepmc   +1 more source

All‐Flex Plasma Patch for In Vivo Delivery of Reactive Species

Advanced Science, EarlyView.
A fully flexible plasma patch enables stable, conformal treatment on complex biological surfaces and enhances transdermal delivery of reactive species. This platform achieves significant tumor suppression in vivo and reveals coordinated regulation of calcium signaling, metabolism, and programmed cell death, providing a promising strategy for safe and ...
Luxiang Zhao, Abulaihaiti Tuergong, Hanshu Yang, Shuang Xue, An Yan, Mingzhen Wang, Weilong Song, Wenzhe Si, Ruixue Wang   +8 more
wiley   +1 more source

JWST interferometric imaging reveals the dusty torus obscuring the supermassive black hole of Circinus galaxy. [PDF]

Nat Commun
Lopez-Rodriguez E, Sanchez-Bermudez J, González-Martín O, Nikutta R, Lau RM, Thatte D, García-Bernete I, Girard JH, Hankins MJ.   +8 more
europepmc   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source