Results 141 to 150 of about 17,522 (280)

Dysfunction of dynactin 1 in motor neuron degeneration

Rinsho Shinkeigaku, 2013
Dynactin 1 is an axon motor protein regulating retrograde transport of various proteins and vesicles including autophagosome. We previously demonstrated that the expression levels of dynacin 1 are markedly reduced in spinal motor neurons of sporadic ALS patients.
Masahisa, Katsuno, Kensuke, Ikenaka, Kaori, Kawai, Gen, Sobue   +3 more
openaire   +3 more sources

A comprehensive analysis of the relationship between inflammasomes and autophagy in human tumors: Recent developments

Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.
The interaction between inflammasomes and autophagy is crucial for maintaining the balance between necessary immune responses and the avoidance of excessive inflammation. Autophagy can inhibit the activation of the NLRP3 inflammasome by degrading endogenous activators, such as damaged mitochondria that produce reactive oxygen species (ROS), as well as ...
Sai Liu, Jingzhou Zhang
wiley   +1 more source

Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome

EBioMedicine, 2017
Parkinsonian Perry syndrome, involving mutations in the dynein motor component dynactin or p150Glued, is characterized by TDP-43 pathology in affected brain regions, including the substantia nigra.
Yuka Hosaka, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Changxu Cui, Taku Arano, Yuzuru Imai, Nobutaka Hattori   +6 more
doaj   +1 more source

USP45 and Spindly are part of the same complex implicated in cell migration [PDF]

, 2018
Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs).
Conte, Claudia, Griffis, Eric, Hickson, Ian D., Perez-Oliva, Ana   +3 more
core   +2 more sources

Whole‐Genome Resequencing Provides Novel Insights Into the Genetic Diversity, Population Structure, and Patterns of Runs of Homozygosity in Mud Crab (Scylla paramamosain)

Evolutionary Applications, Volume 18, Issue 9, September 2025.
ABSTRACT Mud crab (Scylla paramamosain) is an economically important aquaculture crustacean species in China and Southeast Asia countries. However, the catches of wild mud crabs declined sharply due to overfishing and environmental pollution. Therefore, it is necessary to understand the current genetic resources and population history of mud crab (S ...
Xiyi Zhou, Min Ouyang, Yin Zhang, Mhd Ikhwanuddin, Hongyu Ma, Shaopan Ye   +5 more
wiley   +1 more source

Regulation of Axonal Transport by Protein Kinases [PDF]

, 2015
The intracellular transport of organelles, proteins, lipids, and RNA along the axon is essential for neuronal function and survival. This process, called axonal transport, is mediated by two classes of ATP-dependent motors, kinesins, and cytoplasmic ...
Gibbs, KL, Greensmith, L, Schiavo, G
core   +1 more source

A cellular model of TDP‐43 induces phosphorylated TDP‐43 aggregation with distinct changes in solubility and autophagy dysregulation

The FEBS Journal, Volume 292, Issue 18, Page 4870-4897, September 2025.
TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler, Muhammad I. Abeer, Sanaz Arezoumandan, Keyshawn Cox, Tyler L. Petersen, Esther H. Daniel, Carlton L. Cannon III, Angelica Bautista, Kennedy D. Blancher, Alysia M. Bland, Kylie J. Bond, Dominque A. Davis, Jessica M. Francois, Eliana J. McCray, Justin M. Morgan, Jessica L. Pulliam, Zymir A. Robinson, Mykia J. Taylor, James A. Dowell, Nigel J. Cairns, Michael A. Gitcho   +20 more
wiley   +1 more source

DISC1 is needed for the organization of cellular components at the immunological synapse. [PDF]

, 2019
T-cells carry out their immune functions through receptor-based recognition and adhesion to target cells. The cell-cell junction that is created from this connection is known as the immunological synapse (IS); a cellular structure composed of organized ...
Ramakrishnan, Adarsh
core   +1 more source

HIV-1 Engages a Dynein-Dynactin-BICD2 Complex for Infection and Transport to the Nucleus

Journal of Virology, 2018
During HIV-1 infection, the virus must travel across the cytoplasm to enter the nucleus. The host cell motor protein complex dynein has been implicated in HIV-1 intracellular transport. We show that expression of the dynein heavy chain, components of the
Stephanie K. Carnes, Jing-jiao Zhou, C. Aiken   +2 more
semanticscholar   +1 more source

Ropinirole Functions Through a Dopamine Receptor D2‐Independent Mechanism to Ameliorate Amyotrophic Lateral Sclerosis Phenotypes in TARDBP‐Mutant iPSC‐Derived Motor Neurons

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
Ropinirole, a dopamine D2 receptor (DRD2) agonist, protects motor neurons harboring ALS‐linked TARDBP mutations via both DRD2‐dependent and DRD2‐independent mechanisms. Notably, the DRD2‐independent pathway inhibits elevated reactive oxygen species (ROS), abnormal gene expression, aberrant RNA splicing, and neuronal hyperexcitation—key pathogenic ...
Hirotsugu Asano, Tetsuya Kawaguchi, Chris Kato, Satoru Morimoto, Masato Yano, Maki Minaguchi, Daisuke Yasuda, Komei Fukushima, Hideyuki Okano   +8 more
wiley   +1 more source