PLoS ONE, 2019 Microtubules (Mts) are dynamic cytoskeleton structures that play a key role in vesicular transport. The Mts-mediated transport depends on motor proteins named kinesins and the dynein/dynactin motor complex.
Rodolfo M Ortiz Flores +3 more
doaj +1 more source
Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders
Frontiers in Neuroscience, 2015 The Golgi apparatus is a dynamic organelle involved in processing and sorting of lipids and proteins. In neurons, the Golgi apparatus is important for the development of axons and dendrites and maintenance of their highly polarized morphology.
Dick eJaarsma, Casper eHoogenraad
doaj +1 more source
The where, what, and when of membrane protein degradation in neurons [PDF]
, 2017 Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments.
Hiesinger, Peter Robin +2 more
core +1 more source
Structure of dynein–dynactin on microtubules shows tandem adaptor binding
Nature, 2022 Sami Chaaban, A. Carter
semanticscholar +1 more source
RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs
eLife, 2018 Polarised mRNA transport is a prevalent mechanism for spatial control of protein synthesis. However, the composition of transported ribonucleoprotein particles (RNPs) and the regulation of their movement are poorly understood.
Mark A McClintock +6 more
doaj +1 more source
A realistic assessment of methods for extracting gene/protein interactions from free text [PDF]
, 2009 Background: The automated extraction of gene and/or protein interactions from the literature is one of the most important targets of biomedical text mining research.
A Moschitti +32 more
core +4 more sources
A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner
Nature Communications, 2020 Activating adaptors that link dynein to its general cofactor dynactin recruit specific cargoes and regulate dynein’s activity and processive motility in retrograde transport.
In-Gyun Lee +4 more
doaj +1 more source
The Effect of Dynactin Mutations upon Vesicle Trafficking in Living Cells using RNAi [PDF]
, 2010 UMKC Honors ...
Nienaber, Thomas
core
Disease-associated mutations in human BICD2 hyperactivate motility of dynein–dynactin
bioRxiv, 2017 Bicaudal D2 (BICD2) joins dynein with dynactin into a ternary complex (termed DDB) capable of processive movement. Point mutations in the BICD2 gene have been identified in patients with a dominant form of spinal muscular atrophy, but how these mutations
Walter Huynh, R. Vale
semanticscholar +1 more source
Ndel1 disfavors dynein–dynactin–adaptor complex formation in two distinct ways
Journal of Biological Chemistry, 2023 Sharon R. Garrott +5 more
semanticscholar +1 more source