Results 101 to 110 of about 2,698,470 (299)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Dynamic vulnerability assessment. [PDF]

, 2004
With increased terrorist threats in the past few years, it is no longer feasible to feel confident that a facility is well protected with a static security system. Potential adversaries often research their targets, examining procedural and system changes, in order to attack at a vulnerable time.
openaire   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

EFL teachers’ recruitment and dynamic assessment in private language institutes of Iran [PDF]

Journal of English Language Teaching and Learning, 2012
The critical role and effect of teacher assessment in ELT has been ratified by researchers among whom are Darling-Hammond (2000); Knox (2002); Bailey (2006); Davison & Cummins (2007); and Blum (2009).Taking this issue into account, this exploratory study
Ramin Akbari, Elham Yazdanmehr
doaj  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Dynamic assessment and analysis of comprehensive ability of clinical nurse based on hierarchical management

Huli yanjiu, 2015
Objective:On the basis of nurses’ hierarchical management,to carry out dynamic assessment of clinical nurses’ comprehensive ability,so as to provide references for improving the comprehensive ability of nurses and rational use of nurses.Methods:On the ...
杨志兰, 甘红霞, 周建芳
doaj  

Enhancing learners’ emotions in an L2 context through emotionalized dynamic assessment

Studies in Second Language Learning and Teaching, 2013
The aim of this study was to gain more in-depth understanding of students’ emotions in an EFL context by applying dynamic assessment (DA) procedures to the development of learners’ emotional intelligence.
Parisa Abdolrezapour, Mansoor Tavakoli, Saeed Ketabi   +2 more
doaj   +1 more source

A simplified dynamic systems approach for the energy rating of dwellings [PDF]

, 2011
The drive to reduce carbon emissions and energy utilisation, directly associated with dwellings and to achieve a zero carbon home, suggests that the assessment of energy ratings will have an increasingly prioritised role in the built environment. Created
Counsell, John, Khalid, Yousaf Ali, Murphy, Gavin Bruce   +2 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source