Results 71 to 80 of about 1,299,090 (299)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Dynamic capabilities within organizations

RAE: Revista de Administração de Empresas, 2017
The development and use of dynamic capabilities has been a central issue in strategic management and organizational studies over the last decade. While providing a dynamic approach to the first wave of resource-based views on firm operations, dynamic ...
Joaquín Alegre
doaj  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A Model for Technological Capability Improvement in Technology-Based Firms by Using Explanatory Mixed Method (The Sample of Iranian Avionic Firms) [PDF]

بهبود مدیریت, 2013
Aerial Industry with huge market size (100 billion $) and high growth rate (5% annually) is one of the strategic and high technology industries. Avionic sector and its technologies have a significant share of this industry.
Manochehr Manteghi, Seyyed Habibollah Tabatabaiean, Payam Hanafizadeh, Mohammad Naghizadeh   +3 more
doaj  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Exploring small and medium enterprise performance through dynamic capability perspective

The Southern African Journal of Entrepreneurship and Small Business Management
Background: Small and medium enterprises (SMEs) are crucial to both global and national economies. They create jobs, boost competitiveness and drive economic growth.
Dotty Wimpertiwi, Muhtosim Arief, Firdaus Alamsjah, Rini Setiowati   +3 more
doaj   +1 more source

The Strategic Role of Digital Capabilities in Organizational Performance: A Systematic Literature Review [PDF]

International Journal of Information Science and Management
Recognizing the complexity of digital capabilities (DC) is critical in the evolving digital environment. This study explores the conceptualization, dimensions, and strategic impact of DC on organizations by adopting a systematic literature review (SLR ...
Candraningrat Candraningrat, Tanti Handriana, Muchammad Saifuddin   +2 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Relationship Between Big Data Analytics Capability and Organizational Performance: Dynamic Capabilities a Mediate Variable

تنمیة الرافدین
The researchers argue that to leverage big data analytics and realize performance gains, organizations must develop strong big data analytics capabilities.
Abdaladheem D.Jabbar
doaj   +1 more source