Results 91 to 100 of about 1,307,758 (299)

Operational Capabilities: The Secret Ingredient [PDF]

, 2010
We develop a theoretical definition of operational capabilities, based on the strategic management and operations management literature, and differentiate this construct from the related constructs of resources and operational practices, drawing upon ...
Flynn, Barbara B., Melnyk, Steven A., Wu, Sarah Jinhui   +2 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Organization, Evolution, Cognition and Dynamic Capabilities [PDF]

Using insights from ‘embodied cognition’ and a resulting ‘cognitive theory of the firm’, I aim to contribute to the further development of evolutionary theory of organizations, in the specification of organizations as ‘interactors’ that carry ...
Nooteboom, B.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dynamic capabilities from an institutionalist viewpoint

Cadernos EBAPE.BR
The purpose of this paper is to elucidate the effects of strategic, technical and institutional response, in the perspective of dynamic capability facing environmental changes, considering that the literature has few references on how institutional ...
José Bonfim Albuquerque Filho, Sergio Bulgacov, Márcia Ramos May   +2 more
doaj   +1 more source

The role of supply chain management in improving performance of Jordanian small and medium enterprises [PDF]

Problems and Perspectives in Management
Supply chain management practices are always helpful for multinational enterprises in increasing their growth. However, there has always remained an open debate about which practices are helpful for small and medium enterprises (SMEs).
Ahmad Almohtaseb, Jehad Aldehayyat, Adel Al Khattab, Zaid Alabaddi   +3 more
doaj   +1 more source

Entrepreneurship, Dynamic Capabilities and New Firm Growth [PDF]

This paper applies the dynamic capability framework to the study of new firm growth. Using a longitudinal database of 354 firms over their first ten years, we provide an explanation of new firm growth in terms of new product development, R&D, inter-firm ...
F. Stam, Jennifer Telussa, Petra Gibcus
core  

Modeling and position control of a new quad-rotor unmanned aerial vehicle with tilt-wing mechanism [PDF]

, 2008
In this work a dynamic model of a new quadrotor aerial vehicle that is equipped with a tilt-wing mechanism is presented. The vehicle has the capabilities of vertical take-off/landing (VTOL) like a helicopter and flying horizontal like an airplane ...
Aksit, Mahmut Faruk, Akşit, Mahmut Faruk, Cetinsoy, Ertugrul, Gulez, Kayhan, Gülez, Kayhan, Kandemir, İlyas, Kandemir, Ilyas, Oner, Kaan Taha, Unel, Mustafa, Çetinsoy, Ertuğrul, Öner, Kaan Taha, Ünel, Mustafa   +11 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dynamic Capabilities in the German financial services industry

European Journal of Management Issues, 2018
Purpose. The purpose of this work is to investigate processes constituting to Dynamic Capabilities in companies of the German financial services industry. Design/Method/Approach. Exploratory with a qualitative approach and a multiple case study method.
Tobias Oeser
doaj   +1 more source