Results 111 to 120 of about 1,307,758 (299)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
IT DYNAMIC CAPABILITY DEVELOPMENT IN THE CONTEXT OF DATA GENESIS CAPABILITY [PDF]
Dynamic Capabilities are often considered as the factor justifying the different degrees of success of organizations in turbulent environment. However Dynamic Capability development remains a difficult issue to research, with a paucity of work directly ...
Claudio Vitari
core
Business Process Redesign in the Perioperative Process: A Case Perspective for Digital Transformation [PDF]
, 2019 This case study investigates business process redesign within the perioperative process as a method to achieve digital transformation. Specific perioperative sub-processes are targeted for re-design and digitalization, which yield improvement. Based on a
Daily, Sandra +3 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Identifying unobserved heterogeneity in agribusiness firms’ innovation dynamic capabilities
International Journal of Innovation StudiesInnovation dynamic capabilities (IDCs) are crucial for firms in competitive markets, yet their heterogeneous development and utilization remain underexplored.
Beatriz Corchuelo Martínez-Azúa +2 more
doaj +1 more source
Lifestyle Journal, 2023 Purpose: Given the importance of sustainability in the supply chain, the aim of this study was to analyze the effect of supplier environmental damage on managers' perception of the need to develop Green Purchasing Dynamic Capabilities (GPDC), and ...
Vilmar Tondolo +4 more
doaj
Be vicarious: the challenge for project management in the service economy [PDF]
, 2017 Purpose. The paper aims to answer to the following questions: which are the critical dynamic capabilities to survive in the rubber landscape of service economy? Does it exist in service economy a dynamic capabilities provider? Methodology.
Antonio La, Sala +2 more
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Dynamic capabilities in times of economic crisis. A vision of success in international markets. [PDF]
Heliyon, 2023 Ledesma-Chaves P, Jorge Arenas-Gaitán.
europepmc +1 more source