Results 71 to 80 of about 3,940,702 (278)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Model for Technological Capability Improvement in Technology-Based Firms by Using Explanatory Mixed Method (The Sample of Iranian Avionic Firms) [PDF]

بهبود مدیریت, 2013
Aerial Industry with huge market size (100 billion $) and high growth rate (5% annually) is one of the strategic and high technology industries. Avionic sector and its technologies have a significant share of this industry.
Manochehr Manteghi, Seyyed Habibollah Tabatabaiean, Payam Hanafizadeh, Mohammad Naghizadeh   +3 more
doaj  

The Strategic Role of Digital Capabilities in Organizational Performance: A Systematic Literature Review [PDF]

International Journal of Information Science and Management
Recognizing the complexity of digital capabilities (DC) is critical in the evolving digital environment. This study explores the conceptualization, dimensions, and strategic impact of DC on organizations by adopting a systematic literature review (SLR ...
Candraningrat Candraningrat, Tanti Handriana, Muchammad Saifuddin   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Dynamic capabilities: the missing link in CRM investments [PDF]

, 2009
The purpose of this paper is to illustrate the practical application of dynamic capabilities theory to improve investment decisions in customer relationship management (CRM).
Maklan, Stan, Stan Maklan, Simon Knox, Knox, Simon   +3 more
core   +1 more source

Exploring small and medium enterprise performance through dynamic capability perspective

The Southern African Journal of Entrepreneurship and Small Business Management
Background: Small and medium enterprises (SMEs) are crucial to both global and national economies. They create jobs, boost competitiveness and drive economic growth.
Dotty Wimpertiwi, Muhtosim Arief, Firdaus Alamsjah, Rini Setiowati   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Relationship Between Big Data Analytics Capability and Organizational Performance: Dynamic Capabilities a Mediate Variable

تنمیة الرافدین
The researchers argue that to leverage big data analytics and realize performance gains, organizations must develop strong big data analytics capabilities.
Abdaladheem D.Jabbar
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Analysis of dynamic capabilities in the internationalisation process [PDF]

, 2022
Dynamic capabilities are firm’s ability to integrate, build, and reconfigure internal and external resources and competences to address and shape rapidly changing business environments.
Cecchi, Gianfranco
core