Results 81 to 90 of about 298,945 (303)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Dynamic Capabilities and Performance: Strategy, Structure and Environment [PDF]
Long Range Planning, 2013 Dynamic capabilities are widely considered to incorporate those processes that enable organizations to sustain superior performance over time. In this paper, we argue theoretically and demonstrate empirically that these effects are contingent on organizational structure and the competitive intensity in the market.
Wilden, Ralf +3 more
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The emergence of dynamic capabilities in SMEs: A critical realist study [PDF]
, 2012 How do dynamic capabilities develop in small firms? More specifically, what mechanisms account for the emergence of dynamic capabilities in SMEs? The dynamic capabilities perspective synthesises evolutionary theory, the resource based view of the firm ...
Ó hÓbáin, Lorcán
core
Dynamic capabilities within organizations
RAE: Revista de Administração de Empresas, 2017 The development and use of dynamic capabilities has been a central issue in strategic management and organizational studies over the last decade. While providing a dynamic approach to the first wave of resource-based views on firm operations, dynamic ...
Joaquín Alegre
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
How does absorptive capacity influence the origin and evolution of dynamic capabilities [PDF]
, 2010 In this thesis, I deploy a qualitative case-study method to examine the influence of a firm’s absorptive capacity of external knowledge on the origin and evolution of dynamic capabilities.
Lawer, Christopher
core
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
A Model for Technological Capability Improvement in Technology-Based Firms by Using Explanatory Mixed Method (The Sample of Iranian Avionic Firms) [PDF]
بهبود مدیریت, 2013 Aerial Industry with huge market size (100 billion $) and high growth rate (5% annually) is one of the strategic and high technology industries. Avionic sector and its technologies have a significant share of this industry.
Manochehr Manteghi +3 more
doaj