Results 111 to 120 of about 9,289,283 (320)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Sen and the art of educational maintenance: evidencing a capability, as opposed to an effectiveness, approach to schooling [PDF]
, 2012 There are few more widely applied terms in common parlance than ‘capability’. It is used (inaccurately) to represent everything from the aspiration to provide opportunity to notions of innate academic ability, with everything in between claiming ...
Kelly, Anthony
core +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Journal of Leadership & Organizational StudiesA new form of human-machine collaborative capabilities has been called to complement traditional capabilities to ensure higher but more responsible performance in artificial intelligence (AI)-driven organizational environments.
Sahadat Hossain +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
SystemsGrounded in the dynamic capability theory, this study selects three typical manufacturing enterprises as the research subjects. Through longitudinal and cross-case analyses, it delves into the dynamic alignment between the digital servitization ...
Le Zhang, Juhong Chen, Hailin Dong
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Journal of Asian Architecture and Building EngineeringDigitization serves as a critical driver for high-quality development in the construction sector. While performance-driven digital transformation is becoming increasingly prevalent among construction enterprises, the underlying mechanism through which it
Li Xiaolin +5 more
doaj +1 more source
IEEE AccessThis study focuses on building resilience in electric vehicle (EV) supply chain to address the growing challenges of global market uncertainties. Grounded in dynamic capabilities theory, the study identifies and categorizes 16 key factors influencing ...
Yanxuan Li, Vatcharapol Sukhotu
doaj +1 more source