Results 91 to 100 of about 747,103 (297)

China’s Institutional Architecture: A New Institutional Economics and Organization Theory Perspective on the Links between Local Governance and Local Enterprises [PDF]

We start our exploration of China’s institutional change by asking what the China experience can tell us about institutional economics and organization theory.
Hendrischke, H., Krug, B.
core   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Bridging Digital Gaps in Smart City Governance: The Mediating Role of Managerial Digital Readiness and the Moderating Role of Digital Leadership

Smart Cities
Indonesia’s commitment to digital transformation is exemplified by the Gerakan 100 Smart City program, aiming to enhance public sector performance through technology integration.
Ian Firstian Aldhi, Fendy Suhariadi, Elvia Rahmawati, Elisabeth Supriharyanti, Dwi Hardaningtyas, Rini Sugiarti, Ansar Abbas   +6 more
doaj   +1 more source

Institutional reflexivity [PDF]

How can we understand the innovativeness of firms or organizations in general, and how should we assess it in terms of nontechnological innovation? My paper deals with these two questions. The ability of companies to adapt to new circumstances, to create
Moldaschl, Manfred
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A THEORY OF SITUATED CREATIVITY AND ORGANIZATIONAL DYNAMIC CAPABILITIES

IJASOS- International E-journal of Advances in Social Sciences, 2016
Creativity is a vague term that traditionally referred to artistic expression (e.g. painting, singing, sculpting); now creativity is a thought process emphasizing ‘newness’ and can be applied in other disciplines. Creativity when used effectively can improve an organization’s dynamic capabilities exponentially. Situational creativity (SC) is defined as
openaire   +3 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The Alignment Between Digital Servitization Strategies and Digital Servitization Capabilities in Chinese Manufacturing Enterprises: A Multi-Case Study

Systems
Grounded in the dynamic capability theory, this study selects three typical manufacturing enterprises as the research subjects. Through longitudinal and cross-case analyses, it delves into the dynamic alignment between the digital servitization ...
Le Zhang, Juhong Chen, Hailin Dong
doaj   +1 more source