Results 101 to 110 of about 747,103 (297)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Decoding the Factors of Electric Vehicle Supply Chain Resilience: A Structured Categorization for Enhancing Resilience Through Factor Synergies

IEEE Access
This study focuses on building resilience in electric vehicle (EV) supply chain to address the growing challenges of global market uncertainties. Grounded in dynamic capabilities theory, the study identifies and categorizes 16 key factors influencing ...
Yanxuan Li, Vatcharapol Sukhotu
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Logistic Capabilities as a Performance Enabler for Online Retailers

Vikalpa
The digital revolution has significantly contributed towards the growth of online retail, and logistics play a pivotal role in the online retail loop.
Jagdish Bhagwat, Rekha Attri
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The effect of strategic orientation on performance of agribusiness firms in Ethiopia: the mediating role of innovation capability

Cogent Business & Management
Strategic orientation is considered a valuable asset that guides and directs business initiatives, ultimately enhancing the overall performance of the company.
Aregu Asmare Hailu, Chalchissa Amentie Kero, Zinashbizu Lemma Dagne   +2 more
doaj   +1 more source

Modelling effect of valuable resources on franchise outlet performance: Dynamic sensing capability as mediator

South African Journal of Economic and Management Sciences, 2019
Background: Competitive advantage and superior firm performance depend on resources and dynamic capabilities. Aim: This study aims to provide insight into the franchising industry where research on the value-dynamic sensing capability-performance ...
Jilson Zimuto, Rachel Maritz
doaj   +1 more source

Integrated analysis and design of thick composite structures for optimal passive damping characteristics [PDF]

The development of novel composite mechanics for the analysis of damping in composite laminates and structures and the more significant results of this effort are summarized.
Saravanos, D. A.
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Digital Transformation, Strategic Alignment Capability, and Sustainable Competitive Advantage: The Case of the UAE

Systems
Firms globally are transforming digitally to enhance performance through building differentiated organizational capabilities within their digital ecosystem to maximize value.
Madhad Ali Said Al Jabri, Abdelmounaim Lahrech   +1 more
doaj   +1 more source