Results 71 to 80 of about 5,754,265 (320)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanical response of structural rock slope under cyclic dynamic disturbance

Meikuang Anquan
In order to study the stability of slopes containing weakly inter bedded rocks under dynamic disturbance, the dynamic response characteristics of rocks with different inclinations under dynamic cyclic disturbance are investigated through indoor ...
Zhouai ZHANG, Yongjiang YU, Yongjun WANG
doaj   +1 more source

Estimating Dynamic Load Parameters from Ambient PMU Measurements

, 2017
In this paper, a novel method to estimate dynamic load parameters via ambient PMU measurements is proposed. Unlike conventional parameter identification methods, the proposed algorithm does not require the existence of large disturbance to power systems,
Wang, Xiaozhe
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Experimental Study on Instability Mechanism of Red Shale Roadway Under Dynamic Disturbance

Energy Science & Engineering
To delve into the instability mechanism of the surrounding rock in red shale roadways, a bespoke device was chosen to fabricate a physical model, and a similar experiment was conducted with a blasting‐induced disturbance.
Xuewu Wu, Zhenqian Ma, Jinlian Zhou, Chunhng Mao, Jimin Zhang   +4 more
doaj   +1 more source

Experimental study on rock damage and failure induced by multi-source dynamic disturbances

Underground Space
Research into the mechanical behaviour of rock surrounding the deep-buried tunnel under multi-source dynamic disturbance is key to the safety of underground engineering operations.
Han-Yi Liu, Ben-Guo He, Jia-Hua Guan, Hong-Yuan Fu   +3 more
doaj   +1 more source

Performance tradeoffs of dynamically controlled grid-connected inverters in low inertia power systems

, 2017
Implementing frequency response using grid-connected inverters is one of the popular proposed alternatives to mitigate the dynamic degradation experienced in low inertia power systems.
Jiang, Yan, Mallada, Enrique, Pates, Richard   +2 more
core   +1 more source

Comparing coastal storm impact to decadal change in barrier island ecosystems [PDF]

, 2020
Highly dynamic coastal systems respond to disturbance events with a combination of topographic and vegetative changes. Sea level rise impacts on barrier islands have been quantified, but storm effects on vegetation are limited. Here we quantified barrier
Tuley, Philip A
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source