Results 51 to 60 of about 34,001 (234)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

The political life of things: Explorations on material culture and consumption in Evangelical groups in Buenos Aires, Argentina [PDF]

open access: yes, 2017
The aim of the article is to explore the material culture of Neo-Pentecostals´ mega-churches in Buenos Aires City, Argentina. In order to do this, we will reconstruct three consumers’ profile and the way that political senses are put into play.
Algranti, Joaquin Maria
core  

Bifurcations in the Space of Exponential Maps

open access: yes, 2007
This article investigates the parameter space of the exponential family $z\mapsto \exp(z)+\kappa$. We prove that the boundary (in $\C$) of every hyperbolic component is a Jordan arc, as conjectured by Eremenko and Lyubich as well as Baker and Rippon.
C. Bodelón   +23 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A Multi-Agent Approach for Reactionary Delay Prediction of Flights

open access: yesIEEE Access, 2019
Flight schedules are highly sensitive to delays and witness these events on a very frequent basis. In an interconnected and interdependent air transportation system, these delays can magnify and cascade as the flight itineraries progress, causing ...
Yash Guleria   +3 more
doaj   +1 more source

Performing Hybrid Recommendation in Intermodal Transportation – the FTMarket System’s Recommendation Module [PDF]

open access: yes, 2009
Diverse recommendation techniques have been already proposed and encapsulated into several e-business applications, aiming to perform a more accurate evaluation of the existing information and accordingly augment the assistance provided to the users ...
Lazanas, Alexis
core   +1 more source

Optimizing Computation of Recovery Plans for BPEL Applications

open access: yes, 2010
Web service applications are distributed processes that are composed of dynamically bounded services. In our previous work [15], we have described a framework for performing runtime monitoring of web service against behavioural correctness properties ...
Gwen Salaün   +5 more
core   +3 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Connected escaping sets of exponential maps

open access: yes, 2009
We show that for many complex parameters a, the set of points that converge to infinity under iteration of the exponential map f(z)=e^z+a is connected. This includes all parameters for which the singular value escapes to infinity under iteration.Comment:
Rempe, Lasse
core   +1 more source

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

open access: yesArthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg   +20 more
wiley   +1 more source

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