Results 91 to 100 of about 1,078,035 (244)

Numerical Analysis and Safety Assessment of Dynamic Response of Natural Gas Pipelines Under Vibration Loads from High-Speed Railway Tunnels

Applied Sciences
With the rapid expansion of high-speed railway (HSR) networks, the vibration impact on adjacent energy infrastructure has become a critical safety concern.
Meibao Chen, Zhengyu Yan, Xiaofei Jing, Jian Ou, Shangwei Wu, Tao Liu   +5 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Effect of Empty-Hole on Blasting-Induced Damage Evolution and Dynamic Response of Rock

Gaoya wuli xuebao
Aiming at the issue that traditional perimeter blasting easily induces random crack damage in surrounding rocks, this study conducts an in-depth analysis of the damage evolution laws and dynamic response characteristics in empty-hole directional blasting
Tao LI, Yu NI, Zhiliang WANG
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Study on Drill String Fatigue Life in Deepwater Drilling

Shiyou jixie, 2016
Dynamic response of the deepwater drilling platform increases alternating loads of the drilling string.As a consequence,the calculation of drill string fatigue life becomes more complicated.By using the numerical simulation method,a method for studying ...
Wang Jiajia, Chen Jianmin
doaj  

Response Characteristics and Safety Criterion of Double-Arch Tunnel Under Blast-Induced Disturbance from New Tunnel Excavation

Applied Sciences
Blast-induced vibrations from newly constructed tunnels may adversely affect adjacent existing tunnel structures. To ensure the safety of the existing tunnel, it is essential to investigate its dynamic response under blast disturbances.
Youxin Shao, Zhen Zhang, Jinshan Sun, Yingkang Yao, Nan Jiang, Shimao Ma   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Dynamic responses and damage mechanisms of low-rise reinforced concrete frame structures subjected to rockfall impacts

Journal of Asian Architecture and Building Engineering
Combined with the validations of the nonlinear material models, this study addresses the nonlinear dynamic response, damage mechanisms and failure modes of reinforced concrete frame structures under rockfall impacts, utilizing explicit dynamic analysis ...
Tao Tian, Wengao Lu, Haoran Wang
doaj   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source