Results 71 to 80 of about 1,078,035 (244)

Hydrodynamic Performance and Motion Response of a Novel Deep-Water TLP Floating Offshore Wind Turbine

Journal of Marine Science and Engineering
The deployment of floating offshore wind turbines (FOWTs) in deep, typhoon-prone waters like the South China Sea requires platforms with exceptional stability.
Ronghua Zhu, Zongyuan Lai, Chunlong Li, Haiping Qian, Huaqi Yuan, Yingchun Xie, Ke Sun   +6 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Dynamic dq Model of PMSM Using FE‐Based LUTs

IET Electric Power Applications
In recent years, a significant amount of research on modelling of electrical machines was dedicated to high fidelity hybrid models that incorporate pre‐calculated FEA data in the form of lookup tables (LUTs).
Christian Kukura, Judith Apsley, Siniša Djurovic   +2 more
doaj   +1 more source

Analysis of Stress Distribution Law and Dynamic Response of Deep Water Test String

Shiyou jixie, 2020
To study the stress distribution and the influence of internal pressure fluctuations on the dynamic response parameters of deep water test string under different working conditions, the calculation formulas of the axial force, axial stress, radial stress
Tang Xiandi, Sun Qiaolei, Li Zhong, Feng Ding, Wang Erjun, Meng Wenbo, Yan Bangchuan   +6 more
doaj  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Influence of Soil Plugging on Dynamic Soil Response During Simulated Pipe Pile Driving Model Test in Sands

Applied Sciences
The squeezing effect and strike-induced vibration generated by pile driving pose a threat to adjacent structures. To mitigate the squeezing effect, open-ended pipe piles were implemented. However, this type of pile brings a degree of soil-plugging effect,
Songchao Lin, Ye Lu, Chong Zhao
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Dynamic Response and Lubrication Performance of Spur Gear Pair Under Time-Varying Rotation Speeds

Lubricants
The rotation speed directly influences the vibration and lubrication behaviors of gear pairs, but studying the effects of time-varying rotation speeds during their operation poses substantial challenges. The present work proposed an approach to analyzing
Jiaxing Pei, Yuanyuan Tian, Hongjuan Hou, Yourui Tao, Miaojie Wu, Zhigang Guan   +5 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source