Results 81 to 90 of about 1,078,035 (244)

Study on Dynamic Response of Pile Foundation in Elastoplastic Soil Under Horizontal Loads

Buildings
The elastoplastic model can more accurately simulate the elastoplastic behavior of soil in the process of loading, so as to determine the soil resistance more accurately, which holds great significance in calculating the bearing capacity of pile ...
Xiaoqing Gu, Jiaqing Shu, Yuxuan Wang, Pengpeng Wang, Mingxing Zhu   +4 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Vibration Reduction Performance of a Novel Harmonic Frequency Damping Device for Damping Pad Floating Slab Track

Buildings
The stability of the damping pad floating slab track (DPFST) plays a critical role in the operational safety and passenger comfort of urban rail transit systems and represents a significant technical challenge.
Zhaowei Chen, Hanbo Zhang, Qianhua Pu, Pengfei Xu, Zhihui Chen   +4 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Seismic Response Analysis of Concrete Box-Type Subgrade in High-Speed Railways

Applied Sciences
China is prone to frequent earthquakes, impacting both the construction and operation of high-speed railways. The seismic response analysis is essential for the promotion and structural optimization of novel box-type subgrade structures.
Ying-Ying Chen, Hong Xiao, Xu-Guo Song, Shuai-Jie Guo, Bei-Er Luo, Mahantesh M. Nadakatti   +5 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Forced vibration of an axially functionally graded energy pile embedded in temperature-sensitive Winkler soils

Frontiers in Materials
In this study, forced vibration analysis of an energy pile with non-uniformity in vertically inhomogeneous soil is presented considering the non-uniform distributed temperature.
Zhuanzhuan Zhang, Zhao Lu, Zhao Lu
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Simulation Analysis of Seismic Response of Long-distance Suspended Pipeline

Shiyou jixie, 2017
In order to study the dynamic response of the long-distance suspended pipeline under the action of seismic load, the general finite element software ABAQUS has been used to conduct numerical simulation.
Lei Zhen, Liao Heng, Dong Feifei, Du Guofeng   +3 more
doaj  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source