Results 91 to 100 of about 5,322,533 (364)
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Dynamic Fractional Resource Scheduling vs. Batch Scheduling
, 2011 We propose a novel job scheduling approach for homogeneous cluster computing platforms. Its key feature is the use of virtual machine technology to share fractional node resources in a precise and controlled manner. Other VM-based scheduling approaches have focused primarily on technical issues or on extensions to existing batch scheduling systems ...
Casanova, Henri +2 more
openaire +4 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Production Engineering ArchivesVacuum freeze-dried fruit processes consisting of heating and holding are modelled as a mixed batch scheduling with the objective of minimizing the makespan. The jobs differ from each other in job family, size, weight and ready time. The batch processing
Huang JinDian, Hong YingHan, Lin KeYe
doaj +1 more source
IEEE AccessThe advancement of autonomous driving technology presents significant challenges to automotive cyber-physical systems (ACPS) due to the dynamic and random nature of task releases.
Kaiyu Zhao +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Robust And Optimal Opportunistic Scheduling For Downlink 2-Flow Network Coding With Varying Channel Quality and Rate Adaptation [PDF]
, 2014 This paper considers the downlink traffic from a base station to two different clients. When assuming infinite backlog, it is known that inter-session network coding (INC) can significantly increase the throughput of each flow. However, the corresponding
Kuo, Wei-Cheng, Wang, Chih-Chun
core +2 more sources
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Real-Time Scheduling Approaches for Vehicle-Based Internal Transport Systems [PDF]
, 2004 In this paper, we study the problem of scheduling and dispatching vehicles in vehicle-based internal transport systems within warehouses and production facilities.
Koster, M.B.M. (René) de +1 more
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