Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
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Canalization as a stabilizing principle of gene regulatory networks: a discrete dynamical systems perspective. [PDF]
NPJ Syst Biol ApplKadelka C.
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
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Harmonic trophic potentials and memory effects in ecological dynamics in resource-limited ecosystems through the Generalized Lotka-Volterra model with biomass constraints. [PDF]
Theory BiosciMarinho JAO, da Rocha HO, Reis FPP.
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Existence and stability of time-fractional Keller-Segel-Navier-Stokes system with Poisson jumps. [PDF]
Sci RepDivyabala K, Durga N.
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Soliton structures and dynamical characteristics of fractional nonlinear waves in the classical Boussinesq framework. [PDF]
Sci RepRimu NN, Islam MA, Dey P.
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Protein Confinement Decouples Dynamical Heterogeneity from Structural Preordering in Supercooled Monolayer Water. [PDF]
JACS AuJin T, Zhuang W.
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Emergence of multifrequency activity in a laminar neural mass model. [PDF]
PLoS Comput Biolde Palma Aristides R +4 more
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Revisiting Dynamical Theory To Elucidate Friedel's Law Breaking in Low-Energy Electron Diffraction as Strong Evidence of Unidirectional Growth of Monolayer 2H MoS<sub>2</sub>. [PDF]
Nano LettKim D +5 more
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