Results 71 to 80 of about 40,983 (302)
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Understanding and Predicting Nonlinear Turbulent Dynamical Systems with Information Theory
Atmosphere, 2019 Complex nonlinear turbulent dynamical systems are ubiquitous in many areas. Quantifying the model error and model uncertainty plays an important role in understanding and predicting complex dynamical systems.
Nan Chen, Xiao Hou, Qin Li, Yingda Li
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Logical entropy of dynamical systems
Advances in Difference Equations, 2018 The main purpose of the paper is to extend the results of Ellerman (Int. J. Semant. Comput. 7:121–145, 2013) to the case of dynamical systems. We define the logical entropy and conditional logical entropy of finite measurable partitions and derive the ...
Dagmar Markechová +2 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Behavior as Physiology: How Dynamical-Systems Theory Could Advance Psychiatry. [PDF]
Am J Psychiatry, 2021 Salvi JD, Rauch SL, Baker JT.
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Interpretable predictions of chaotic dynamical systems using dynamical system deep learning
Scientific ReportsMaking accurate predictions of chaotic dynamical systems is an essential but challenging task with many practical applications in various disciplines.
Mingyu Wang, Jianping Li
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Dynamic Equations, Control Problems on Time Scales, and Chaotic Systems
Chaos Theory and Applications, 2023 The unification of integral and differential calculus with the calculus of finite differences has been rendered possible by providing a formal structure to study hybrid discrete-continuous dynamical systems besides offering applications in diverse fields
Martin Bohner
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