Results 131 to 140 of about 35,988 (242)

Dynamin 2 Regulates Mitochondrial Mitotic Fission in Pulmonary Hypertension. [PDF]

Circ Res
Dasgupta A, Chen KH, Wu D, Yerramilli VS, Lima PDA, Martin AY, Bentley RET, Ott BP, Nandani T, Mewburn JD, Tian L, Al-Qazazi R, Emon IM, Colpman P, Jefferson L, Noordhof C, Jones O, Hindmarch CCT, Archer SL.   +18 more
europepmc   +1 more source

The Zuo Jin Wan Formula Reverses Cisplatin Resistance in Gastric Cancer by Inhibiting the Mitochondrial Translocation of Dynamin‐Related Protein 1 and Its Mediated Mitochondrial Fission and Mitophagy

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Background Gastric cancer is a major global health concern characterized by high incidence and mortality rates. One of the key challenges in treating gastric cancer is the development of resistance to chemotherapy drugs like cisplatin (DDP). This study aimed to investigate the efficacy of Zuo Jin Wan (ZJW), a traditional Chinese medicine, in ...
Zhuo Zhao, Meijie Yuan, Xiao Yang, Qing Ji, Guobin Liu, Qingfeng Tang, Jian Sun   +6 more
wiley   +1 more source

Dynamins maintain nuclear envelope homeostasis and genome stability. [PDF]

Nat Commun
Aveleira C, Martial T, Carrique L, Gaspar R, Caulino-Rocha A, Myatt I, Wendler F, Lascaux P, Le Claire M, Bancroft J, Smythe C, Ramadan K, Raimundo N, Milosevic I.   +13 more
europepmc   +1 more source

β‐Elemene Triggers Drp1‐Dependent Mitochondrial Fission Through CDK1/Cyclin B1 Signaling in Cervical Cancer Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This study reveals a novel molecular mechanism by which the natural sesquiterpene β‐Elemene exerts anti‐tumor effects in cervical cancer. β‐Elemene treatment promotes the activation of the CDK1/Cyclin B1 kinase complex. Activated CDK1/Cyclin B1, in turn, phosphorylates the mitochondrial fission protein Drp1 at serine 616.
Zhifang Li, Ling Tang, Mingyan Wang, Qiong Yu, Chen Chen, Jiyi Xia, Xiaolan Yu   +6 more
wiley   +1 more source

Failure of Hepatic Insulin Clearance via CEACAM1-Mediated Endocytosis: The Missing Physiological Link Between Proinsulin Misfolding, Hyperinsulinemia, and Metabolic Complications in Type 2 Diabetes, Obesity, and NAFLD. [PDF]

Probl Endokrinol (Mosk)
Akl MM, Ahmed A.
europepmc   +1 more source

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie, Qun Zeng, Hongrui Wang, Meihua She   +3 more
wiley   +1 more source

Decapod iridescent virus 1 (DIV1) enters hematopoietic <i>Cherax quadricarinatus</i> cells via caveola-mediated endocytosis in a pH-dependent manner. [PDF]

J Virol
Zheng Q, Chen X, Zhao F, Zhang J, Chen J.   +4 more
europepmc   +1 more source

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source

DNM2 lipid binding drives centronuclear myopathy and represents a potential therapeutic target. [PDF]

JCI Insight
Gómez-Oca R, Massana-Muñoz X, Reiss D, De Carvalho Neves J, Diedhiou N, Silva-Rojas R, Cowling BS, Goret M, Laporte J.   +8 more
europepmc   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source