Results 131 to 140 of about 37,365 (212)

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

In situ mapping of late-stage biomechanical coordination during clathrin-mediated endocytosis. [PDF]

Nat Commun
Wu B, Luo T, Zhu Y, Zhang X, Song D, Lin Y, Sun Y, Huang TX, Cheng X, Fang N.   +9 more
europepmc   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

High-fat diet-responsive DNM1 promotes hepatocellular carcinoma progression and predicts poor prognosis in viral-associated patients. [PDF]

Am J Cancer Res
Chen PM, Huang HY, Chen HH, Chen RF, Chiang EI.   +4 more
europepmc   +1 more source

After delivery: How recipient cells shape the fate and function of transplanted mitochondria

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Recipient‐cell handling shapes how transplanted mitochondria contribute after delivery, linking donor competence, recipient state and exposure duration to intracellular fate. The framework matches transient rescue, sustained functional support and durable mitochondrial DNA correction to the evidence and product attributes required for each therapeutic ...
Zhi‐Yuan Zhang, Bo‐Quan Qin, Shi‐Zhou Wu, Hui Zhang   +3 more
wiley   +1 more source

Quantification of lipid sorting during clathrin-mediated endocytosis. [PDF]

Nat Cell Biol
Lennartz HM, da Costa Nunes S, Böhlig K, Chhatre A, Šachl R, Kuhn SM, Moneta L, Barahtjan P, Yee Yau W, Iglesias-Artola JM, Hof M, Opálka L, Modes CD, Honigmann A, Nadler A.   +14 more
europepmc   +1 more source

Broken Engines of Immunity: Mitochondrial Dysfunction in T Cells Across Cancer and Complex Pathologies

European Journal of Immunology, Volume 56, Issue 10, October 2026.
Mitochondria not only play a fundamental role in energy production but also regulate physiological processes, including metabolism, homeostasis, and immune function. In T cells, they control activation, differentiation, and function. Their dysfunction contributes to immune exhaustion in cancer, chronic infections, and ageing. This review examines these
Carolina Brescia, Giuseppe Viglietto, Rosario Amato   +2 more
wiley   +1 more source

Panax notoginseng Saponins Accelerate Diabetic Wound Repair by Minimizing Mitochondrial Dysfunction and Inhibiting Pyroptosis of Macrophage via Regulating Ephx2/11,12‐EET Axis

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Panax notoginseng saponins (PNS) accelerate diabetic wound healing via targeting the Ephx2/11,12‐EET axis in macrophages. PNS inhibits Ephx2 expression to elevate 11,12‐EET levels, which restores mitochondrial homeostasis by regulating mitochondrial dynamic proteins, reduces mtROS production, and subsequently suppresses NLRP3 inflammasome‐mediated ...
Nan Chen, Bo Zhu, Cai‐hua Sun, Tong Hou   +3 more
wiley   +1 more source

Nanoscale junctional membrane curvatures recruit BIN1 and SNX9 for endothelial collective migration. [PDF]

J Cell Biol
Janssen V, de Kraker H, Aaron JS, de Haan A, de Heer I, Khuon S, Da Silva J, Driessen AJM, Chew TL, Tan JME, Lagendijk AK, Angulo-Urarte A, Huveneers S.   +12 more
europepmc   +1 more source

SIRT3‐Dependent Actions of Berberine: From Molecular Therapies to Toxicity

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
This study reveals that berberine's therapeutic versatility in metabolic, cardiovascular, and hepatic disorders stems from its modulation of the mitochondrial protein Sirt3. Understanding this mechanism explains both its broad efficacy and its organ‐specific toxicity, positioning berberine as a promising mitochondrial epigenetic modulator whose ...
Dareuosh Shackebaei, Seyed Shahram Miraghaee, Faegheh Farhadi, Abolfazl Akbarzadeh, Fatemeh Yarmohammadi   +4 more
wiley   +1 more source