Results 111 to 120 of about 37,365 (212)

The Senokine Gas6 Promotes Aortic Valve Calcification Through CaMKII–DRP1–Mediated Terminal Scission of Mitochondrial‐Derived Vesicles

Aging Cell, Volume 25, Issue 11, November 2026.
In age‐associated calcific aortic valve disease (CAVD), human valve tissues and calcifying human valvular interstitial cells (hVICs) exhibit senescence‐associated features, while calcifying hVICs hypersecrete mitochondrial‐derived vesicles (MDVs). Donut‐shaped mitochondria serve as physical platforms for MDV budding, whereas Gas6 promotes Ca2+–CaMKII ...
Yaoyu Zhang, Jialiang Zhang, Yanjiani Xu, Wenhua Lei, Fei Xu, Junli Li, Zisong Wei, Bo Su, Shuang Liu, Jing Zhou, Hongde Li, Junpeng Ran, Weiya Li, Tuerhongjiang Tuerdi, Xiaojiao Wang, Zhi Fang, Fangyang Huang, Mao Chen   +17 more
wiley   +1 more source

Nanoparticles improve targeting and efficacy of endocytosis inhibitors. [PDF]

RSC Adv
Szewczyk-Roszczenko OK, Roszczenko P, Misztalewska-Turkowicz I, Dudchak R, Yushyn I, Shepeta Y, Holota S, Bielawska A, Czarnomysy R, Lesyk R, Wilczewska A, Vassetzky Y, Bielawski K.   +12 more
europepmc   +1 more source

Genetic and Pharmacologic Inhibition of Myostatin Restores Muscle Mass in a Dynamin 2-Related Centronuclear Myopathy Mouse Model. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Autosomal dominant centronuclear myopathy (ADCNM), most commonly caused by mutations in the dynamin 2 (DNM2) gene, is a rare congenital myopathy characterized by progressive muscle weakness and atrophy. Myostatin, a key negative regulator of skeletal muscle mass, has shown therapeutic potential in several models of neuromuscular ...
Anne-Cécile D, David A, Mathias V, Valentine A, Chloé P, Quentin D, Esra K, Sidney C, Emmanuelle G, Louise C, Alexandre G, Josiane C, Aja P, Maximilien B, Baptiste M, Christophe H, Schaeffer L, Olli R, Marc B, Rémi M, Damien F.   +20 more
europepmc   +2 more sources

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, Volume 14, Issue 8, Page 2401-2418, November 2026.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

From Closed to Mighty: How GTP-Induced Allosteric Dynamics, Dimerization, and Membrane Binding Transform a Bacterial Dynamin-like Protein. [PDF]

J Chem Inf Model
Schumann W, Bundschuh BF, Loschwitz J, Strodel B.   +3 more
europepmc   +1 more source

Endocytosis and Endocytic Neurotrophin Signaling in Developing Spiral Ganglion Neurons. [PDF]

Int J Mol Sci
Doolittle S, Pak K, Chavez E, Housley GD, Kurabi A, Ryan AF.   +5 more
europepmc   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Role of the Host Membrane Trafficking Protein Dynamin 2 in Cell-to-Cell Spread of Bacterial Pathogens. [PDF]

Cells
Ireton K.
europepmc   +1 more source

Increased Expression of Desmin and Vimentin Impairs Mitochondrial Function and Reduces Contractility via G0S2 in Bladder Smooth Muscle

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Our previous study demonstrated that elevated levels of desmin and vimentin reduce BSM contractility. This study shows that the reduced BSM contractility is associated with mitochondrial impairment. G0/G1 switch gene 2 (G0S2) is upregulated in desmin‐ and vimentin‐overexpressing BSM.
Elham Javed, Chellappagounder Thangavel, Karthik Thangavel, Joseph Hypolite, Isabelle Gamache, Yilin Wang, Sankar Addya, Darin Mak, Furqan Syed, Jyotsna Mishra, Vilas Desai, Pragnya Das, Dominic R. Villalba, Alok Bhushan, Shey‐Shing Sheu, Sunday A. Shoyele, Erin L. Seifert, Jose G. Teodoro, Steven S. An, Raymond B. Penn, Deepak A. Deshpande, Ettickan Boopathi   +21 more
wiley   +1 more source

Dynamin inhibitor dynasore modulates longitudinal bone growth in a hormetic manner. [PDF]

BMC Biol
Marchan-Alvarez JG, Koikkara S, Zhou R, Nazaraliyev A, Wiklander OPB, Newton PT.   +5 more
europepmc   +1 more source